Optimizing Anti-Thymocyte Globulin Exposure to Improve Survival Chances after Hematopoietic Cell Transplantation for Acute Leukemia and Myelodysplastic.

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Presentation transcript:

Optimizing Anti-Thymocyte Globulin Exposure to Improve Survival Chances after Hematopoietic Cell Transplantation for Acute Leukemia and Myelodysplastic Syndrome Rick Admiraal, Stefan Nierkens, Moniek de Witte, Eefke Petersen, Gerjan Fleurke, Luka Verrest, Catherijne A.J. Knibbe, Monique Minnema, Reinier Raymakers, Charlotte van Kesteren, Jurgen Kuball, Jaap-Jan Boelens Biology of Blood and Marrow Transplantation Volume 23, Issue 3, Pages S45-S46 (March 2017) DOI: 10.1016/j.bbmt.2016.12.009 Copyright © 2016 Terms and Conditions

Figure 1 Median ATG exposures after HCT following different ATG dosing regimens. Pane A: Current UMCU/HOVON regimen; Panel B: Regimen proposed by Walker et al.; Panel C: EBMT guidelines; Panel D: Individualized regimen. Green areas: optimal ATG exposure after HCT; Red areas: underexposure (left side of green area) and overexposure (right side of green area). Symbols represent patients of different body wights. Y-axis: peripheral blood lumphocyte count before infusion of first dose of ATG. Biology of Blood and Marrow Transplantation 2017 23, S45-S46DOI: (10.1016/j.bbmt.2016.12.009) Copyright © 2016 Terms and Conditions

Figure 2 Biology of Blood and Marrow Transplantation 2017 23, S45-S46DOI: (10.1016/j.bbmt.2016.12.009) Copyright © 2016 Terms and Conditions