Hepatic CD141+IFNλ+ DC subset: One against all? Claudia Wegscheid, Khalil Karimi, Gisa Tiegs  Journal of Hepatology  Volume 60, Issue 1, Pages 9-11 (January 2014) DOI: 10.1016/j.jhep.2013.10.007 Copyright © 2013 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Possible role of CD141+ DC subsets in the immune response. Upon viral infection CD141+CLEC9A+ DCs become activated and release IFNlambda (IFN-λ). Subsequently, conventional CD8+ T cells are recruited to the liver to clear the infection. On the other hand, ILT3+ILT4+CD141+ DCs become activated with several stimuli and might induce the regulation of the immune response, e.g., by induction of regulatory T cells (Tregs). This might promote the healing and regeneration process in the liver. Journal of Hepatology 2014 60, 9-11DOI: (10.1016/j.jhep.2013.10.007) Copyright © 2013 European Association for the Study of the Liver Terms and Conditions