Role of the cytoplasmic pattern recognition receptor Nod2 in Coxiella burnetii infection  M. Benoit, Y. Bechah, C. Capo, P.J. Murray, J.L. Mege, B. Desnues  Clinical Microbiology and Infection  Volume 15, Pages 154-155 (December 2009) DOI: 10.1111/j.1469-0691.2008.02270.x Copyright © 2009 European Society of Clinical Infectious Diseases Terms and Conditions

Fig. 1 Host responses to C. burnetii infection. (a) BMDM from control (white bars) and Nod2–/– (black bars) were infected with C. burnetii for 8 h and transcripts encoding TNF, IL-10, RANTES and MCP-1 were quantified by quantitative RT-PCR. Results are expressed as the ratio of expression levels in infected cells vs. uninfected cells (n = 4). (b, c and d) Control (white bars) and Nod2–/– (black bars) mice were infected and C. burnetii-specific circulating antibodies were measured over the course of infection (b). Bacterial load in the spleen (c) and in the liver (d) was monitored by quantitative PCR. *p < 0.005, **p < 0.0005. Clinical Microbiology and Infection 2009 15, 154-155DOI: (10.1111/j.1469-0691.2008.02270.x) Copyright © 2009 European Society of Clinical Infectious Diseases Terms and Conditions