Predict the splitting patterns of the protons in a given molecule. Week 12 Analyse a proton NMR spectrum to make predictions about the number of non-equivalent protons and possible structures for the molecule. Predict the splitting patterns of the protons in a given molecule. © Pearson Education Ltd 2009 This document may have been altered from the original

Different combinations of spin states for protons in adjacent H atoms Week 12 Different combinations of spin states for protons in adjacent H atoms © Pearson Education Ltd 2009 This document may have been altered from the original

Proton NMR spectrum of methyl propanoate showing splitting patterns Week 12 Proton NMR spectrum of methyl propanoate showing splitting patterns © Pearson Education Ltd 2009 This document may have been altered from the original 3

Week 12 Describe the identification of O–H and N–H protons by proton exchange using D2O. © Pearson Education Ltd 2009 This document may have been altered from the original

Water, H2O, and heavy water, D2O Week 12 Water, H2O, and heavy water, D2O © Pearson Education Ltd 2009 This document may have been altered from the original

Proton NMR spectrum of ethanol, C2H5OH: (a) without D2O; (b) with D2O Week 12 Proton NMR spectrum of ethanol, C2H5OH: (a) without D2O; (b) with D2O © Pearson Education Ltd 2009 This document may have been altered from the original 6

Compound with molecular formula C3H7NO2 Week 12 Compound with molecular formula C3H7NO2 © Pearson Education Ltd 2009 This document may have been altered from the original 7

Predict the splitting patterns of the protons in a given molecule. Week 12 Analyse a proton NMR spectrum to make predictions about the number of non-equivalent protons adjacent to a given proton, and possible structures for the molecule. Predict the splitting patterns of the protons in a given molecule. © Pearson Education Ltd 2009 This document may have been altered from the original

Proton NMR spectra of ClCH2CH2COOH and CH3CHClCOOH, both in D2O Week 12 Proton NMR spectra of ClCH2CH2COOH and CH3CHClCOOH, both in D2O © Pearson Education Ltd 2009 This document may have been altered from the original

Proton NMR spectra of two esters of C4H8O2 Week 12 Proton NMR spectra of two esters of C4H8O2 © Pearson Education Ltd 2009 This document may have been altered from the original 10

Proton NMR spectrum of 2-chloropropane, CH3CHClCH3 Week 12 Proton NMR spectrum of 2-chloropropane, CH3CHClCH3 © Pearson Education Ltd 2009 This document may have been altered from the original 11

Proton NMR spectrum of 1,2-dichloroethane, ClCH2CH2Cl Week 12 Proton NMR spectrum of 1,2-dichloroethane, ClCH2CH2Cl © Pearson Education Ltd 2009 This document may have been altered from the original 12

Week 12 Explain that NMR spectroscopy is the same technology as that used in magnetic resonance imaging (MRI). © Pearson Education Ltd 2009 This document may have been altered from the original