Making the Case for Metabolic Surgery in Patients With Obesity and T2DM
Introduction/Overview
Obesity and T2DM: Key Correlations
Improvements in Metabolic Parameters Pre- and Post-Roux-en-Y Surgery
Post-Hoc Analysis Look AHEAD: The Importance of ≥ 10% Weight Loss
Weight Loss Is Difficult, Weight Loss Maintenance Even More So
Overall Strategy for the Treatment of Obesity[a,b]*
Obesity: Imbalance of Energy Regulation
SCALE: Change in Body Weight (%), Liraglutide vs Placebo
Roux-en-Y Gastric Bypass Induces System-Wide Physiological Changes[a,b]
Mechanisms of Bariatric Surgery[a-c]
Factors Associated With Long-Term Weight Loss Maintenance
"The Biggest Loser" and the Persistence of Metabolic Adaptation
Early Treatment Response and Stopping Rules
Characteristics of More and Less Successful Weight Loss Losers After Bariatric Surgery
Bariatric (Metabolic) Surgery Modalities
Bariatric Surgery Modalities: BPD
Diabetes Surgery Summit-II Recommendations
Despite Advances in Treatment, a Significant Proportion of Patients With T2DM Have Not Reached Target HbA1c Levels
Bariatric Surgery vs Intensive Medical Therapy for T2DM: STAMPEDE Trial
Clinical Trial Results of HbA1c Levels After Roux-en-Y Surgery vs Medical Treatment
Impact of Bariatric Surgery on Life Expectancy in Persons With T2DM and Severe Obesity
Surgery Leads to Lower Costs and Greater Health Gains vs Optimal Medical Management
Prevention of T2DM With Bariatric Surgery vs Control: SOS Study
AACE/TOS/ASMBS Guidelines: Criteria for Bariatric Surgery Recommendation
Meta-Analysis of Bariatric Surgery Risk
Anemia and Nutritional Deficiencies Associated With Bariatric Surgery
Summary and Conclusions
Abbreviations
Abbreviations (cont)