Making the Case for Metabolic Surgery in Patients With Obesity and T2DM

Introduction/Overview

Obesity and T2DM: Key Correlations

Improvements in Metabolic Parameters Pre- and Post-Roux-en-Y Surgery

Post-Hoc Analysis Look AHEAD: The Importance of ≥ 10% Weight Loss

Weight Loss Is Difficult, Weight Loss Maintenance Even More So

Overall Strategy for the Treatment of Obesity[a,b]*

Obesity: Imbalance of Energy Regulation

SCALE: Change in Body Weight (%), Liraglutide vs Placebo

Roux-en-Y Gastric Bypass Induces System-Wide Physiological Changes[a,b]

Mechanisms of Bariatric Surgery[a-c]

Factors Associated With Long-Term Weight Loss Maintenance

"The Biggest Loser" and the Persistence of Metabolic Adaptation

Early Treatment Response and Stopping Rules

Characteristics of More and Less Successful Weight Loss Losers After Bariatric Surgery

Bariatric (Metabolic) Surgery Modalities

Bariatric Surgery Modalities: BPD

Diabetes Surgery Summit-II Recommendations

Despite Advances in Treatment, a Significant Proportion of Patients With T2DM Have Not Reached Target HbA1c Levels

Bariatric Surgery vs Intensive Medical Therapy for T2DM: STAMPEDE Trial

Clinical Trial Results of HbA1c Levels After Roux-en-Y Surgery vs Medical Treatment

Impact of Bariatric Surgery on Life Expectancy in Persons With T2DM and Severe Obesity

Surgery Leads to Lower Costs and Greater Health Gains vs Optimal Medical Management

Prevention of T2DM With Bariatric Surgery vs Control: SOS Study

AACE/TOS/ASMBS Guidelines: Criteria for Bariatric Surgery Recommendation

Meta-Analysis of Bariatric Surgery Risk

Anemia and Nutritional Deficiencies Associated With Bariatric Surgery

Summary and Conclusions

Abbreviations

Abbreviations (cont)