Volume 50, Issue 1, Pages (July 2006)

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Volume 50, Issue 1, Pages 119-125 (July 2006) Facilitatory Neuromodulative Effect of Duloxetine on Pudendal Motor Neurons Controlling the Urethral Pressure: A Functional Urodynamic Study in Healthy Women Sönke Boy, André Reitz, Barbara Wirth, Peter A. Knapp, Peter M. Braun, Axel Haferkamp, Brigitte Schurch European Urology Volume 50, Issue 1, Pages 119-125 (July 2006) DOI: 10.1016/j.eururo.2005.12.020 Copyright © 2005 European Association of Urology Terms and Conditions

Fig. 1 Urethral resting pressures (mean and SD bars) before and 4h after administration of duloxetine. Mean pressure over the entire urethra (p mean entire urethra), maximal pressure over the entire urethra (p maximal entire urethra), mean pressure over the proximal (p mean proximal third), middle (p mean middle third), and distal (p mean distal third) third of the urethra are shown (urethral pressure profiles n=66). European Urology 2006 50, 119-125DOI: (10.1016/j.eururo.2005.12.020) Copyright © 2005 European Association of Urology Terms and Conditions

Fig. 2 Motor thresholds for urethral sphincter contraction in response to transcranial magnetic stimulation before and 4h after administration of duloxetine. European Urology 2006 50, 119-125DOI: (10.1016/j.eururo.2005.12.020) Copyright © 2005 European Association of Urology Terms and Conditions

Fig. 3 Two urethral pressure profiles (UPPs) under single-pulse magnetic stimulation of the sacral roots for both conditions during baseline and follow-up 4h after 40mg duloxetine (original data from subject 11). European Urology 2006 50, 119-125DOI: (10.1016/j.eururo.2005.12.020) Copyright © 2005 European Association of Urology Terms and Conditions

Fig. 4 Cut-out magnification and overlay from Fig. 3 from two UPPs during baseline and follow-up 4h after 40mg duloxetine (original data from subject 11). European Urology 2006 50, 119-125DOI: (10.1016/j.eururo.2005.12.020) Copyright © 2005 European Association of Urology Terms and Conditions

Fig. 5 Amplitudes of urethral pressure spikes before and 4h after administration of duloxetine. European Urology 2006 50, 119-125DOI: (10.1016/j.eururo.2005.12.020) Copyright © 2005 European Association of Urology Terms and Conditions