Pathophysiology of Irritable Bowel Syndrome

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Presentation transcript:

Pathophysiology of Irritable Bowel Syndrome

Rome III Criteria: Irritable Bowel Syndrome

A Renaissance in Understanding Causes of IBS

IBS-C Mimics Evacuation Disorder

Peripheral Mechanism: Altered Colonic Motility

Abnormal Transit in Diarrhea and in Constipation

Bile Acids in IBS-C and IBS-D

Peripheral Mechanism: Small Bowel and Colonic Sensing and Response

Peripheral Mechanism: Small Bowel Mucosal Permeability

Layers of Protection: Intestinal Mucosa

Peripheral Mechanism: Colonic Mucosal Permeability

Peripheral Mechanism: Mucosal Immune Activation

Peripheral Mechanism: Colonic Microbiome

Current Treatment Is Guided by Symptom-Based Diagnostic Criteria

IBS Symptoms: Mechanisms and Diagnosis

Actions of Treatments Based on Pathophysiology

Diagnostic Implications

Future Research

Future Research (cont)

Abbreviations

References

References (cont)