Workshop Overview Obtaining 3D Macromolecular Models Understanding The Models Sharing Structure-Function Information Martz – May 2010

Workshop Overview Obtaining 3D Macromolecular Models Published Empirical (Crystallographic or NMR) Homology Models (Theoretical Models Are Grossly Inaccurate) Understanding The Models Sharing Structure-Function Information Martz – May 2010

Workshop Overview Obtaining 3D Macromolecular Models Understanding The Models FirstGlance in Jmol ( + links to Key Resources) Proteopedia Sharing Structure-Function Information Martz – May 2010

Workshop Overview Obtaining 3D Macromolecular Models Understanding The Models Sharing Structure-Function Information: Custom Molecular Scenes without Tears Polyview-3D: publication quality; animations for Powerpoint Proteopedia: a wiki; rotating molecules; on-line Martz – May 2010

Gal 4 Transcriptional Regulator Protein. Lysine 18 sits in DNA Major Groove recognizing CGG. (1d66) Martz – May 2010 – 1d66

Animation Created by Polyview-3D Gal4:DNA (1d66) Animation Created by Polyview-3D (using PyMOL) Martz – May 2010 – 1d66

Mechanosensitive channel Animation by Polyview-3D using PyMOL (Morph between 2oau & 2vv5) Morph is also animated in Jmol in Proteopedia