Spread of KPC-producing carbapenem-resistant Enterobacteriaceae: the importance of super-spreaders and rectal KPC concentration A. Lerner, A. Adler,

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Spread of KPC-producing carbapenem-resistant Enterobacteriaceae: the importance of super-spreaders and rectal KPC concentration A. Lerner, A. Adler, J. Abu-Hanna, S. Cohen Percia, M. Kazma Matalon, Y. Carmeli Clinical Microbiology and Infection Volume 21, Issue 5, Pages 470.e1-470.e7 (May 2015) DOI: 10.1016/j.cmi.2014.12.015 Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 The distribution of the number of carbapenem-resistant Enterobacteriaceae (CRE) colonies detected in the carriers' vicinity. The vicinity of six super-spreaders (18% of the patients) accounted for 80% of the environmental colonies. Clinical Microbiology and Infection 2015 21, 470.e1-470.e7DOI: (10.1016/j.cmi.2014.12.015) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 2 Correlation between environmental contamination with carbapenem-resistant Enterobacteriaceae (eCRE) and rectal CRE concentration. Rectal CRE concentration was measured from rectal swabs as (a) the ratio of CRE to total aerobic bacteria (CRE/TAB) (r2 = 0.175) and (b) the ratio of Klebsiella pneumoniae carbapenemase (KPC) -producing bacteria to total flora (blaKPC gene copies/16S rDNA gene copies; r2 = 0.351). Grey circles represent super-spreaders; white rhombuses represent low-level spreaders; and black rhombuses represent non-spreaders. Clinical Microbiology and Infection 2015 21, 470.e1-470.e7DOI: (10.1016/j.cmi.2014.12.015) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions