Dengue Prevention in Asia

Part 1: Overview of Dengue

What Is Dengue?

WHO Dengue Case Classification

Prevalence and Disease Burden of Dengue

Dengue Serotypes

Global Distribution of Dengue, 2012

Global Dengue Transmission Map - Thailand

Social Impact of Dengue

Asymptomatic Individuals and Transmission

Getting Dengue More Than Once

Why Does Severe Dengue Occur?

Prevention of Dengue Infection

Dengue CYD-TDV

Efficacy of CYD-TDV

Efficacy of CYD-TDV (cont)

Part 2: Dengue Q&A

Question: Why is the dengue vaccine not recommended in children aged < 9 years?

Vaccination Age Recommendations

Question: What did the WHO recommend in July 2016 for countries considering introducing the CYD-TDV?

WHO Recommendation, July 2016

Question: What did the additional analysis provided to WHO conclude?

Results of Additional Analysis of Dengue Vaccine Data

Question: Why is there a higher risk of severe dengue in seronegative people who receive the vaccine?

Higher Severe Dengue Risk in Seronegative People Who Receive the Vaccine

Higher Severe Dengue Risk in Seronegative People Who Receive the Vaccine (cont)

Question: What happens to people who have breakthrough dengue after being vaccinated?

Breakthrough Dengue After Vaccination

Question: Has the WHO updated it position as a result of this analysis?

Updated WHO Position, December 2017

Question: Why did the vaccine manufacturer request a label update in November 2017?

Vaccine Label Update Request

Question: Why have some countries recently begun re-examining their use of dengue vaccine?

Re-Examination of Vaccine Use in Asia

Question: Are people previously infected with dengue likely to know that they had the disease?

Awareness of Previous Dengue Infection

Question: How can a physician determine whether or not a patient should receive the vaccine?

Deciding Whether to Vaccinate

Questions from patients and parents

Considerations When Vaccinating Children

Other Considerations

Vaccine Side Effects

Summary

Abbreviations