a b p= 0,2 0,4 0,6 0,8 1 1,2 BCL11A * Relativeexpression 0,2 0,4 0,6

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a b p=0.01446 0,2 0,4 0,6 0,8 1 1,2 BCL11A * Relativeexpression 0,2 0,4 0,6 0,8 1 1,2 MAP3K2 p=0.002496 ** Relativeexpression 0,2 0,4 0,6 0,8 1 1,2 GSK3B Relativeexpression p=0.002218 ** Supplementary Figure 7. a, NUDT16 transduced MOLT-4 cells show cytoplasmic expression. b, Validation of the mRNA expression levels by RT-qPCR following Actinomycin D treatment of the RIP-derived candidates BCL11A, MAP3K2 or GSK3B in NUDT16 (NUDT16-OE) or empty vector-transduced (Mock) MOLT-4 cells. Restoration of NUDT16 expression destabilizes all mRNAs.