Turner’s Syndrome Background: Described in 1938 by Henry Turner Cause isolated in 1960 (loss of one/part of one sex chromosome) Physical Symptoms: Short Stature (mean height < 5 feet) Failure to develop secondary sex characteristics Maldeveloped Ovaries (infertility; high risk of ovarian cancer) Variety of medical problems: cardiovascular, kidney, pancreas, skeletal, thyroid: MARKED VARIABLE EXPRESSIVITY Minor physical anomalies: webbed neck, low set ears, puffy hands and feet: MARKED VARIABLE EXPRESSIVITY Behavioral Symptoms: Normal intelligence Normal personality (problems of self-esteem and body image that may be associated with physical anomalies) Lowered spatial-visualization and quantitative reasoning ? Higher stereotypical feminine interests

Turner’s Syndrome Karyotype http://www.genecrc.org/site/lc/lc2e.htm