Nurses' Health Study: Risk of hypertension associated with >1000 µg/day of folate vs <200 µg/day Cohort Absolute risk reduction (cases per 1000 person-years)

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Nurses' Health Study: Risk of hypertension associated with >1000 µg/day of folate vs <200 µg/day Cohort Absolute risk reduction (cases per 1000 person-years) Multivariate relative risk reduction (95% CI) p for trend NHS II (age 26-46) 8 0.54 (0.45-0.66) <0.001 NHS I (age 43-70) 6 0.82 (0.69-0.97) 0.05 Forman JP et al. JAMA 2005; 293:320-329.

Nurses' Health Study: Risk of hypertension associated with >800 µg/day of supplemental folate vs <200 µg/day among women with dietary intake <200 µg/day Cohort Multivariate risk reduction (95% CI) p for trend NHS II (age 26-46) 0.55 (0.32-0.94) 0.03 NHS I (age 43-70) 0.61 (0.34-1.11) 0.05 Forman JP et al. JAMA 2005; 293:320-329.