Figure 4 Paradoxical immune reconstitution inflammatory syndrome

Slides:

Advertisements

Similar presentations

1 Copyright © 2014 Elsevier Inc. All rights reserved. Chapter 43 Nervous System Complications of Systemic Viral Infections John E. Greenlee.

Advertisements

Neurology Resident and Fellow Section

Nat. Rev. Neurol. doi: /nrneurol

Silent Brain Infarcts by Yi-Cheng Zhu, Carole Dufouil, Christophe Tzourio, and Hugues Chabriat Stroke Volume 42(4): March 28, 2011 Copyright ©

MRI and possible differentiating features with nonconventional MRI

Figure 1 Perivenous distribution of multiple sclerosis lesions

Figure 2. A patient with multifocal nodular lesions diagnosed with CNS tuberculosis A patient with multifocal nodular lesions diagnosed with CNS tuberculosis.

Nat. Rev. Neurol. doi: /nrneurol

Figure 1 Initial brain imaging (A–C) patient 1; (D–F) patient 2; (G–I) patient 3; (J–L) patient 4; and (M) patient 2. Initial brain imaging (A–C) patient.

Figure 4 Host damage from infection-related inflammatory

Nat. Rev. Neurol. doi: /nrneurol

How I treat and manage strokes in sickle cell disease

Reversible posterior leukoencephalopathy syndrome and silent cerebral infarcts are associated with severe acute chest syndrome in children with sickle.

7.1b. Contrast coronal T1 Wtd MRI 7.1c. Contrast sagittal T1 Wtd MRI

Nat. Rev. Neurol. doi: /nrneurol

Figure 4 Neuromyelitis optica spectrum disorder brain lesions

Figure 1 Brain MRI findings in the present case

Figure 4. Brain imaging and neuropathologic demonstration of Epstein-Barr virus (EBV) encephalitis in patient PT-10 Brain imaging and neuropathologic demonstration.

Figure 5 Corticosteroid treatment can reduce brain

Figure 2 Evolution of MRI abnormalities in faciobrachial dystonic seizures Axial fluid- attenuated inversion recovery (FLAIR)-weighted images from patient.

Figure 1 Coronal MRI images showing the evolution of white matter abnormality and atrophy of patient 1 Coronal MRI images showing the evolution of white.

Figure 2 Pathological features of opportunistic infections of the CNS

Nat. Rev. Neurol. doi: /nrneurol

Figure Facial photograph during headache attack and brain and upper cervical cord MRI Facial photograph during headache attack and brain and upper cervical.

Nat. Rev. Neurol. doi: /nrneurol

Volume 52, Issue 6, Pages (June 2015)

Figure 3 Example of venous narrowing

Figure 2 Examples of lesions with and without central veins

Nat. Rev. Neurol. doi: /nrneurol

Fluid-attenuated inversion recovery magnetic resonance imaging at the onset of the clinical investigation (A, B) and 2 months later (C, D). Fluid-attenuated.

Images of a patient (patient 14 in the Table) with a benign meningioma, distinct histopathologic subtype. Images of a patient (patient 14 in the Table)

Figure 1 MRI head in faciobrachial dystonic seizures (A) Axial fluid-attenuated inversion recovery image from patient 3 in table 2 shows T2-weighted hyperintensity.

Figure Radiographic and histopathologic findings (A) Brain MRI at presentation shows multiple areas of T2 hyperintensity in the mesial temporal lobes,

Figure 1. Prebiopsy and postbiopsy MRI

Figure 3 MRI findings in opportunistic infections of the CNS

Figure Brain MRI and biopsy specimens from the pontine lesion

Nat. Rev. Neurol. doi: /nrneurol

Figure 1 MRI, pathology, and EEG findings(A) Axial fluid-attenuated inversion recovery (FLAIR) MRI sequences of the brain showing right frontal and parietal.

Figure 2 T2-weighted and subtraction images

Figure 2 Exemplary MRI of a patient with contrast enhancement on postcontrast FLAIR MRI of a 54-year-old patient with viral meningitis caused by varicella-zoster.

Figure Radiologic and pathologic findings Fluid-attenuated inversion recovery (FLAIR) sequence with a single large T2-hyperintense signal involving the.

Figure 2 Example of venous narrowing

Figure 1 MRI of inflammatory myelitis before and after treatment

Figure 3. Brain imaging and neuropathologic studies in patient PT-5 diagnosed with progressive multifocal leukoencephalopathy Brain imaging and neuropathologic.

Nat. Rev. Neurol. doi: /nrneurol

Figure Genetic deletion and MRI changes with EHMT1 deletion

Anatoly Shuster, MD, Mehran Midia, MD

Nat. Rev. Neurol. doi: /nrneurol

Figure MRI brain 6 weeks post admission (A–C) Symmetrical high signal changes on fluid-attenuated inversion recovery sequences predominantly affecting.

Figure 1 Evolution of MRI findings during interleukin (IL)–7 therapy

Figure 1 Imaging of disease onset and treatment response Repeat MRI scans including fluid-attenuated inversion recovery (FLAIR) (A) and T2 fast field echo.

Figure 1 Radiologic features of patients with white matter syndromes in association with NMDA receptor antibodies Radiologic features of patients with.

Figure 1 MRI findings over time

Figure 1 Brain MRI Brain MRI (A) Axial fluid-attenuated inversion-recovery images show perilesional edema in both cerebellar hemisphere and hypointense.

Imaging of patient 1. Imaging of patient 1. (A) Muscle MRI of both legs performed at the age of 5 years: coronal gadolinium-enhanced T1-weighted sequence.

Figure 1 Detailed overview of treatment course and paraclinical findings Maximum intensity projection maps of supratentorial inversion recovery images.

Figure 1 MRIs (case 1)‏ MRIs (case 1) An enlarging T2 lesion in the cerebral white matter near the angular gyrus and a new lesion in the left middle cerebellar.

Figure 1 Imaging and histopathologic characteristics of patients with CNS-FHL Imaging and histopathologic characteristics of patients with CNS-FHL FLAIR.

Figure 2 Characteristic MRI features of adult leukodystrophies

Figure A 57-year-old man with relapsing-remitting MS (RRMS) and new-onset ataxia A 57-year-old man with relapsing-remitting MS (RRMS) and new-onset ataxia.

Figure 4 Patient 3 MRI evolution over time

Figure 3 Patient 2 MRI evolution over time before relapse

Figure 2 Patient 1 MRI evolution over time

Images from the case of an 8-year-old female patient with complex I mitochondrial disease, which was diagnosed when the patient was older than 3 years.

MR scan of brain fluid-attenuated inversion recovery (FLAIR) (A) and short tau inversion recovery (STIR) (B, C) showing asymmetrical hyperintensities affecting.

MR scans of brain and spine: (A) sagittal T2 image showing signal change in the posterior spinal cord between C3 and T6. MR scans of brain and spine: (A)

Axial magnetic resonance imaging (MRI) of a 30 year old man with relapsing remitting multiple sclerosis (MS) showing multiple periventricular lesions:

MR scan of brain (coronal sections of fluid attenuation inversion recovery (FLAIR) sequences) in a patient with corticobasal syndrome, showing generalised.

Figure 1 MRIs MRIs (A and B) Axial FLAIR images of the brain demonstrate multifocal parenchymal lesions including the right hippocampus, right midbrain,

Chronic CNS-IRIS without coinfection.

Presentation transcript:

Figure 4 Paradoxical immune reconstitution inflammatory syndrome Figure 4 | Paradoxical immune reconstitution inflammatory syndrome. This representative series of MRI scans depicts a case of paradoxical immune reconstitution inflammatory syndrome (IRIS) attributed to toxoplasmosis-associated encephalitis in an HIV-negative immunocompromised patient with lymphopenia who underwent allogeneic stem cell transplantation. a | Post-gadolinium fluid-attenuated inversion recovery (FLAIR) MRI sequence. b | Pre-gadolinium T1-weighted MRI sequence. c | Post-gadolinium T1-weighted sequence. The MRI sequences depicted here show numerous foci of FLAIR hyperintensity and gadolinium enhancement in the cortex, left thalamus and parietal–occipital regions, indicating toxoplasmosis-associated lesions (white). Perilesional enhancement and oedema are particularly prominent on T2-FLAIR MRI (part a) and surround the left thalamic, right temporal, left frontal and left parietal–occipital lesions. Haemorrhage into the large left basal ganglia lesion can be seen on the pre-contrast T1 image (part b). Bowen, L. N. et al. (2016) HIV-associated opportunistic CNS infections: pathophysiology, diagnosis and treatment Nat. Rev. Neurol. doi:10.1038/nrneurol.2016.149