Volume 18, Issue 1, Pages (February 2011)

Slides:

Advertisements

Similar presentations

Multiple Sclerosis Alan Chen 4/1/14. General Information Other names: disseminated sclerosis or encephalomyelitis disseminata Inflammatory disease that.

Advertisements

Chapter 8.2: The Nervous System. Neuroglia  Astrocytes  Largest and most numerous  Maintain blood-brain barrier  Isolates CNS from circulation  Capillaries.

Modulation of circulating cell–endothelial cell interaction by erythropoietin in lean and obese mice with cecal ligation and puncture Vidula Vachharajani,

Date of download: 6/30/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Quantification and Functional Characterization of.

Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease C Bjartmar, J.R Wujek, B.D Trapp Journal of.

Harry Irving, Hung Jiew Lee, John Parratt

Effector stage CC chemokine receptor-1 selective antagonism reduces multiple sclerosis-like rat disease Sana Eltayeb, Dan Sunnemark, Anna-Lena Berg,

Copyright © 2010 American Medical Association. All rights reserved.

Interferon beta-1b exacerbates multiple sclerosis with severe optic nerve and spinal cord demyelination Yoko Warabi, Yoh Matsumoto, Hideaki Hayashi

Autoimmune theory of the pathogenesis of multiple sclerosis (MS)

Contribution of nitric oxide synthase (NOS) in blood–brain barrier disruption during acute focal cerebral ischemia in normal rat Mohammad T. Mohammadi,

Volume 16, Issue 2, Pages (August 2009)

Figure Model contrasting the potential role of antibodies to myelin oligodendrocyte glycoprotein (MOG) or aquaporin-4 (AQP4) in opticospinal inflammationMOG-specific.

Roopa Bhat, Lawrence Steinman Neuron

Neuromyelitis Spectrum Disorders

Schwann cell injuries of radial nerve after lead (Pb) exposure in rats

The role of lymphatic vessels in the heart

Hypoglycemic and hypolipidemic effect and antioxidant activity of chronic epigallocatechin-gallate in streptozotocin-diabetic rats Mehrdad Roghani, Tourandokht.

The relevance of animal models in multiple sclerosis research

Stephen L. Hauser, Jorge R. Oksenberg Neuron

Figure 4 Neuromyelitis optica spectrum disorder brain lesions

Marie C. Harrisingh, Charles ffrench-Constant Cell Stem Cell

Fumitaka Sato, Hiroki Tanaka, Faris Hasanovic, Ikuo Tsunoda

Figure 3 Antibodies to MOG using different secondary antibodies: Anti-human IgG (H + L), IgG1, or IgM(A) Comparison of binding to full-length myelin oligodendrocyte.

Enhancing Central Nervous System Remyelination in Multiple Sclerosis

Volume 20, Issue 1, Pages (February 2013)

Volume 21, Issue 1, Pages (February 2014)

Figure 1 Percent positivity by clinical feature Overall, 6

Oxidative stress in autism

Multiple sclerosis and cerebral endothelial dysfunction: Mechanisms

Doruk Erkan, Elizabeth Kozora, Michael D. Lockshin Pathophysiology

Increasing rates of head melanoma in Nordic countries

Junad Khan, Noma Noboru, Andrew Young, Davis Thomas Pathophysiology

Figure 1 Integrative model of NMO/SD pathogenesis

Figure 1 Biomarkers associated with different clinical phases in MS

Synovial biology and T cells in rheumatoid arthritis

Serum cholinesterase activity in the diagnosis of nonalcoholic fatty liver disease in type 2 diabetic patients O.O. Ogunkeye, E.K. Chuhwak, A.A.E. Otokwula

Michael T. LeVasseur, Neal D. Goldstein, Seth L. Welles

Chemokines and leukocyte trafficking in rheumatoid arthritis

Volume 18, Issue 1, Pages (February 2011)

Figure 4 Neuropathology of MOG and AQP4 antibody–associated demyelinating lesions in the brain The biopsy specimen revealed a small actively demyelinating.

Influence of obesity on sepsis

L-Arginine supplementation enhances antioxidant activity and erythrocyte integrity in sickle cell anaemia subjects M.O. Kehinde, S.I. Ogungbemi, C.N.

Cardiac and autonomic responses to change in posture or vitamin C supplementation in sickle cell anemia subjects S.I. Jaja, M.O. Kehinde, S.I. Ogungbemi

Typical imaging findings.

Volume 19, Issue 4, Pages (September 2012)

Yanjie He, Tianhan Kong, Weihua Dong Pathophysiology

Catherine J. Hunter, Isabelle G. De Plaen Pathophysiology

Current concepts in the surgical approach to necrotizing enterocolitis

(A) Anti-MOG antibodies measured ...

Protein kinase C and synaptic dysfunction after cardiac arrest

A Curious Case of NMO Transverse Myelitis – Mystery Solved. Anna M

David A. Clark, Upender K. Munshi Pathophysiology

Figure 4 Confirmatory cohorts to assess MOG-IgG1 assay(A) All 81 aquaporin-4 (AQP4)- seropositive patients (blue) from the Oxford National neuromyelitis.

Figure 1 Kaplan-Meier estimation of time to neuromyelitis optica (NMO) conversion and development of motor disability Kaplan-Meier estimation of time to.

Angiotensin converting enzyme inhibitor captopril modifies conditioned place preference induced by morphine and morphine withdrawal signs in rats Hojjatallah.

Skin cancer epidemic in a wireless world

Zhiyong Ming, Seppo Pietikainen, Osmo Hänninen Pathophysiology

Increasing incidence of brain tumours in sparsely populated areas

Figure 7 VEGF as a mediator of neuroinflammatory disease

The impact of psychogenic stressors on oxidative stress markers and patterns of CYP2E1 expression in mice liver Oksana Maksymchuk, Mykola Chashchyn

Age and cerebral circulation

Volume 14, Issue 1, Pages (May 2007)

Error processing in patients with Alzheimer's disease

Obesity and vascular dysfunction

Volume 13, Issue 1, Pages (February 2006)

Low dietary folate impairs glucose tolerance and plasma lipid profile in oral contraceptive-treated rats L.A. Olatunji, A.O. Soladoye Pathophysiology

Risk factors and mechanisms of non-alcoholic steatohepatitis

Figure Overview of patients with demyelinating diseases, presence of clinical symptoms frequently associated with NMDAR encephalitis, and antibody status.

Figure 1 Full-length MOG cell-based assay using a serum dilution of 1:160 as a cutoff for positivity (red line in both plots)(A) Myelin olidgodendrocyte.

Presentation transcript:

Volume 18, Issue 1, Pages 69-79 (February 2011) Neuromyelitis optica and opticospinal multiple sclerosis: Mechanisms and pathogenesis Jun-ichi Kira Pathophysiology Volume 18, Issue 1, Pages 69-79 (February 2011) DOI: 10.1016/j.pathophys.2010.04.008 Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Destruction of an astrocyte foot process by complement-activating anti-aquaporin-4 (AQP4) antibody. Once the anti-AQP4 IgG1 antibody crosses the blood–brain barrier, it binds to AQP4 on the astrocyte foot process, and fixes and activates complements. Activated complements mobilize neutrophils and eosinophils, which then produce severe tissue damage, and cause secondary demyelination. Disruption of the astrocyte foot process prolongs resolution from vasogenic edema caused by inflammation. Pathophysiology 2011 18, 69-79DOI: (10.1016/j.pathophys.2010.04.008) Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Two subtypes of NMO/OSMS with LESCLs in Asians. There are NMO-IgG-seropositive and -seronegative cases with NMO/OSMS, which show some difference in clinical features. Pathologically, there are also two subtypes of NMO: one presenting with preferential AQP4 loss and one that does not. Even in MS plaques, AQP4 loss is occasionally seen. Some cases show both features in different lesions. Ab: antibody; AQP4: aquaporin-4; LESCLs: longitudinally extensive spinal cord lesions; MS: multiple sclerosis; NMO: neuromyelitis optica; OSMS: opticospinal multiple sclerosis. Pathophysiology 2011 18, 69-79DOI: (10.1016/j.pathophys.2010.04.008) Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Two hypothetical mechanisms of MS and NMO. In (A), myelin is a primary target of T cells and antibodies in MS, whereas in NMO, astrocytes are a primary target of anti-AQP4 antibody. In (B), myelin-specific T cells initiate CNS inflammation and antibodies recognizing various components of CNS antigens modify the clinicopathological features. Ab: antibody; AQP4: aquaporin-4; CPMS: chronic progressive multiple sclerosis; MOG: myelin-oligodendrocyte glycoprotein; MS: multiple sclerosis; NMO: neuromyelitis optica; OSMS: opticospinal multiple sclerosis. Pathophysiology 2011 18, 69-79DOI: (10.1016/j.pathophys.2010.04.008) Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions