*Lipoma: -well-circumscribed -homogenous -fatty cut surface -soft visit https://grosspathology-sites.uchicago.edu/page/lipoma for references

Bland-looking nuclei…small and at the periphery Mature fatty tissue Bland-looking nuclei…small and at the periphery Large one fat vacuole Visit http://www.pathologyoutlines.com/topic/softtissueadiposelipoma.html for references

Heterogenous cut surface Fixed to the skin and may ulcerate Large Firm to hard Fleshy Heterogenous cut surface Fixed to the skin and may ulcerate Malignant soft tissue tumor …this example is liposarcoma Visit http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2014;volume=57;issue=4;spage=617;epage=619;aulast=Khurana for references

This cell is characteristic and it is called: lipoblast liposarcoma Visit https://en.wikipedia.org/wiki/Liposarcoma for references

Intradermal nevus (the most common type of nevus) Epithelioid benign cells maturation In melanoma: in addition to atypia and invasion, the maturation is lost Lymphocyte-like benign cells Spindle benign cells Visit https://emedicine.medscape.com/article/1962932-overview#a7 for references

The cytoplasm of the cell is filled with this dark brown pigment Pigmented nevus The cytoplasm of the cell is filled with this dark brown pigment (melanin) Visit https://basicmedicalkey.com/melanocytic-nevi/ for references

…each cell within lacuna has 1 nucleus Normal cartilage …small nuclei …each cell within lacuna has 1 nucleus Visit http://medcell.med.yale.edu/histology/connective_tissue_lab/hyaline_cartilage.php for references

Chondrosarcoma …notice the atypia …some cells have more than 1 nucleus in each cytoplasm (binucleation and multinucleation) Visit http://www.pathologyoutlines.com/topic/bonechondrosarcoma.html for references

Malignant glands with severe architectural disturbance Lung tissue Adenocarcinoma …May be metastatic or primary …do immunostaining Visit http://medind.nic.in/ici/t13/i4/icit13i4p356.htm for references

Stromal reaction (fibrosis) around cancer…= desmoplasia Metastatic adenocarcinoma in lymph node Visit https://commons.wikimedia.org/wiki/File:Metastatic_Colonic_Adenocarcinoma_in_Lymph_Node.jpg for references

Metastatic squamous cell carcinoma in lymph node Keratin pearl

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Melanoma …irregular borders …heterogenous with different colors …underlying tissue destruction …large size Visit http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/dermatology/cutaneous-malignant-melanoma/ for references

moderate grade squamous dysplasia (changes in lower two thirds) Most common site of these changes is in transition zone (junction between ecto- and endocervix) Severe squamous dysplasia (full-thickness changes)… = squamous cell carcinoma in situ moderate grade squamous dysplasia (changes in lower two thirds) Low grade squamous dysplasia (changes only in lower third) Robbins and Cotran pathologic basis of disease 9th edition CIN = cervical intraepithelial neoplasia The main cause is HPV Can be detected by cervical (Pap) smear before squamous cell carcinoma occurs Ectocervix: stratified squamous non-keratinized

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