Hematology and Circulatory System

Structures of the circulatory system Blood Heart Arteries Veins Capillaries 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Blood Hemat- = blood -ology = the study of The average adult has 8 – 10 pints. 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Blood One drop of blood contains: 5 million RBCs 250,000-500,000 platelets 7,500 WBCs Red blood cells live 120 days. Make new blood cells 2 million per second! 2.01 Remember the structures of the circulatory system

Structures of the blood Plasma Erythrocytes Leukocytes Thrombocytes 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Plasma Straw-colored liquid Blood without cellular components 55% of the blood’s volume Water Plasma proteins Nutrients Electrolytes Hormones, vitamins, and enzymes Waste products Plasma Cellular elements 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Plasma proteins Fibrinogen - Necessary for blood clotting, synthesized in liver Albumin - From the liver, helps maintain blood’s osmotic pressure and volume Globulin Gamma globulin Prothrombin - helps blood coagulate. Vitamin K necessary for prothrombin synthesis Plasma Cellular elements 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Erythrocytes Biconcave disk Hemoglobin - Gives red color, heme is iron and globin is protein Transportation Oxygen Carbon dioxide Arterial blood Lots of oxygen Bright red Venous blood Lots of CO2 Dark crimson 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Erythrocytes 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Leukocytes Larger than erythrocytes Five types Leuk/o/cytes – white cells 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Leukocytes Agranulocytes Lymphocytes Monocytes 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Leukocytes Granulocytes Neutrophils Eosinophils Basophils Phagocytosis Process when white cells surround, engulf, and digest harmful bacteria….used by granulocytes and monocytes 2.01 Remember the structures of the circulatory system

Agranulocyte VS Granulocyte 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Clip https://www.youtube.com/watch?v=zQGOcOUBi6s 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Thrombocytes Smallest of solid components of blood Synthesized in red marrow Not cells, composed of fragments of cells Necessary for the initiation of the blood clotting process 2.01 Remember the structures of the circulatory system

What does it really look like all together?? 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Clip https://www.youtube.com/watch?v=CRh_dAzXuoU 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Life span of blood cells... 2.01 Remember the structures of the circulatory system

Blood types Inherited from parents What are the types of blood? Inherited from parents Determined by presence or absence of an antigen on the surface of the red blood cell 2.01 Remember the structures of the circulatory system

Check your knowledge of medical history... In 1901, the Austrian immunologist Karl Landsteiner discovered that blood may be grouped into four main types. Based on the reaction that resulted when blood from different individuals were mixed. 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Blood types Someone with type A antigen has B antibodies Someone with type B antigen has A antibodies Someone with type AB antigen has no antibodies Someone with type O antigen has A and B antibodies 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Rh factor Rhesus (Rh) factor is an inherited trait that refers to a specific protein found on the surface of red blood cells (antigen). Blood used in transfusions must match donors for Rh status as well as for ABO blood type. Although Rh factor doesn't affect the patient’s health, it can affect pregnancy. 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Rh factor In 1940, the Rh factor was discovered as a result of studying Rhesus monkeys. When blood from monkeys was injected into rabbits and guinea pigs, it clotted. 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Rh factor If the blood has the protein, the patient is Rh positive. If the blood lacks the protein, the patient is Rh negative. Did you know??? 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system If the mom gets pregnant again with another Rh + positive, her anti Rh antibodies will attack the baby’s blood, causing ERYTHROBLASTOSIS FETALIS. RHO Gam will destroy any baby blood cells in the mom, & her immune system won’t produce antibodies. 2.01 Remember the structures of the circulatory system

Structures of the circulatory system Heart Did you know your heart is the size of your fist? 2.01 Remember the structures of the circulatory system

Heart Can you identify the structures of the heart? The heart is a double pump. 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Heart Check your knowledge... Aorta Superior vena cava Pulmonary artery Aortic semilunar valve Pulmonary vein Right atrium Left atrium Tricuspid valve Bicuspid (mitral) valve Inferior vena cava Pulmonary semilunar valve Right ventricle Left ventricle Septum Apex 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Layers of the heart Left atrium Right atrium Pericardium Myocardium Endocardium Right ventricle Left ventricle 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system

Blood supply to the Heart – from CORONARY ARTERIES Heart Sounds = lubb dupp Blood supply to the Heart – from CORONARY ARTERIES Heart Sounds = lubb dupp

Control of Heart Contractions SA (sinoatrial) NODE = PACEMAKER Located in right atrium SA node sends out electrical impulse Impulse spreads over atria, making them contract Travels to AV Node AV (atrioventricular) NODE Conducting cell group between atria and ventricle Carries impulse to bundle of His

BUNDLE OF HIS Conducting fibers in septum Divides into R and L branches to network of branches in ventricles PURKINJE FIBERS Impulse shoots along Purkinje fibers causing ventricles to contract

Conduction system of heart beats AV bundle or Bundle of HIS Septum 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system EKG…What exactly is it??? An EKG is a test that shows the electrical functions of the heart The P wave is left and right atrial depolarization(change in the cell's membrane potential to a more positive state) 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system QRS…What is it???? depolarization of the right and left ventricles of the human heart. 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system T Wave…what is it??? repolarization (or recovery) of the ventricles 2.01 Remember the structures of the circulatory system

What about abnormal EKGs??? Atrial Fibrillation: In AF, the heart's electrical signals don't begin in the SA node. Instead, they begin in another part of the atria or in the nearby pulmonary veins. The signals don't travel normally. They may spread throughout the atria in a rapid, disorganized way. This can cause the atria to fibrillate. 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Abnormal EKG’s Ventricular Tachycardia: regular and fast heart rate that arises from improper electrical activity in the ventricles of the heart 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Abnormal EKG’s Asystole: (flatline) a state of no electrical activity from the heart and therefore no blood flow. It results in cardiac arrest 2.01 Remember the structures of the circulatory system

Vessels of the circulatory system ARTERIES Carry oxygenated blood away from the heart to the capillaries Elastic, muscular and thick-walled Transport blood under very high pressure Arteries > arterioles > capillaries 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Arteries 2.01 Remember the structures of the circulatory system

Vessels of the circulatory system VEINS Carry deoxygenated blood away from capillaries to the heart Veins contain a muscular layer, but less elastic and muscular than arteries Thin walled veins collapse easily when not filled with blood Veins have values that permit flow of blood only in direction of the heart Veins > Venules > Capillaries 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Veins 2.01 Remember the structures of the circulatory system

Structures of the circulatory system Capillaries The smallest blood vessels Connect arterioles to venules One cell thick…made of endothelial tissue 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Capillaries 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system Blood Pressure Surge of blood when heart pumps creates pressure against the walls of the arteries SYSTOLIC PRESSURE - measured during the contraction phase – (contraction phase of the heart is called systole) DIASTOLIC PRESSURE - measured when the ventricles are relaxed – (relaxation phase is called diastole) 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system BP and Pulse sites Average systolic = 120 Average diastolic = 80 PULSE - alternating expansion and contraction of an artery as blood flows through it. Pulse Sites: Brachial, Carotid, Radial, Popliteal, Pedal – Where are they??? Find pulse sites and take BP 2.01 Remember the structures of the circulatory system

Common pulse sites Practice locating pulse sites... 2.01 Remember the structures of the circulatory system

What are the functions of blood? Transportation What does the blood transport? Why is this an important function? 2.02 Understand the functions and disorders of the circulatory system

What are the functions of blood? Regulation How does the blood regulate heat? Aids in distribution of heat formed in more active tissues like skeletal muscle How does the blood regulate acid/base balance? 2.02 Understand the functions and disorders of the circulatory system

2.01 Remember the structures of the circulatory system Acid/Base Balance A pH of 7 is neutral. The lower the pH, the more acidic the blood. A variety of factors affect blood pH including what is ingested, vomiting, diarrhea, lung function, endocrine function, kidney function, and urinary tract infection. The normal blood pH is tightly regulated between 7.35 and 7.45. 2.01 Remember the structures of the circulatory system

What are the functions of blood? Protection What function of the blood serve to protect the body? What is the relevance to health? 2.02 Understand the functions and disorders of the circulatory system

2.01 Remember the structures of the circulatory system Erythropoiesis Manufacturing of RBC’s, occurs in bone marrow, until adolescence, then in short and flat bones 2.01 Remember the structures of the circulatory system

2.02 Understand the functions and disorders of the circulatory system Erythrocytes hemolysis What is it? Rupturing of RBCs Where does it occur? blood transfusion reaction or other disease What is the lifetime of an erythrocyte? 120 days What happens to old erythrocytes? Broken down by spleen and liver; iron content used to make new RBC’s Starts here 2.02 Understand the functions and disorders of the circulatory system

2.02 Understand the functions and disorders of the circulatory system Inflammation What is inflammation? 2.02 Understand the functions and disorders of the circulatory system

2.01 Remember the structures of the circulatory system INFLAMMATION 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system INFLAMMATION Dirty nail punctures skin Bacteria enter and multiply Injured cells release histamines Blood vessels dilate and become permeable, releasing inflammatory exudate Blood flow to damaged area increases Neutrophils move toward bacteria and destroy them by phagocytosis 2.01 Remember the structures of the circulatory system

2.01 Remember the structures of the circulatory system AGGLUTINATION 2.01 Remember the structures of the circulatory system

Disorders ANEMIA Deficiency in number or % of red blood cells IRON-DEFICENCY ANEMIA Usually in women, children and adolescents Deficiency of iron in the diet causing in sufficient hemoglobin synthesis Treat with iron supplements and green, leafy vegetables

2.01 Remember the structures of the circulatory system PERNICIOUS ANEMIA Caused by deficiency of B12 or intrinsic factor (produced by stomach mucosa, necessary for absorption of B12) Symptoms – dyspnea, pallor, fatigue, & neurologic changes Treatment – injections of B12 APLASTIC ANEMIA Bone marrow does not produce enough red & white blood cells Caused by drugs or radiation therapy 2.01 Remember the structures of the circulatory system

SICKLE CELL ANEMIA Chronic blood disease inherited from both parents Causes the red cells to form in abnormal sickle shape Siclke cells break easily & carry less oxygen Occurs primarily in blacks Treatment – blood transfusions COOLEY’S ANEMIA Also known as Thalassemia Major Caused by a defect in hemoglobin Affects people of Mediterranean descent

POLYCYTHEMIA Too many red blood cells are formed May be a temporary condition that occurs at high altitude EMBOLISM Air, blood clot, cancer cells, fat, etc. That is carried by the bloodstream until it reaches an artery too small for passage Also known as a “moving blood clot” THROMBOSIS The formation of a blood clot in a blood vessel The blood clot is a THROMBUS

HEMATOMA Localized clotted mass of blood found in an organ, tissue or space Caused by an injury that can cause a blood vessel to rupture HEMOPHILIA Hereditary Missing clotting factor Blood clots slow or abnormally Sex-linked – transmitted genetically from mother to sons Treat with missing clotting factor, avoid trauma THROMBOCYTOPENIA Not enough platelets Blood will not clot properly

LEUKEMIA Malignant condition Overproduction of immature white blood cells Hinders synthesis of red cells SEPTICEMIA Presence of pathogens or toxins in the blood

Pus- cream colored liquid Abscess- pus filed cavity Pyrexia- fever Leukocytosis-increase in white blood cell count (>10,000 per cubic centimeter) Edema-excessive fluid in tissues

Circulatory disorders Varicose veins Prevention Wear sunscreen Elevate legs when resting Wear elastic support stockings Eating fiber diets Exercise Weight control 2.02 Understand the functions and disorders of the circulatory system

Circulatory disorders Transient ischemic attack 2.02 Understand the functions and disorders of the circulatory system

Circulatory disorders Pulmonary edema 2.02 Understand the functions and disorders of the circulatory system

Circulatory disorders Peripheral vascular disease How can PVD be prevented? 2.02 Understand the functions and disorders of the circulatory system

Circulatory disorders Myocardial infarction 2.02 Understand the functions and disorders of the circulatory system

Circulatory disorders Murmurs What is the most common instrument used to detect murmurs? 2.02 Understand the functions and disorders of the circulatory system

Circulatory disorders Heart failure 2.02 Understand the functions and disorders of the circulatory system

Circulatory disorders Angina pectoris Severe chest pain that arises from heart not receiving enough O2 2.02 Understand the functions and disorders of the circulatory system

2.01 Remember the structures of the circulatory system Aneurysm Ballooning of an artery through a thinned out arterial wall; caused by weakening of blood vessel Pain and pressure Treatment of brain aneurysm: surgery 2.01 Remember the structures of the circulatory system

2.02 Understand the functions and disorders of the circulatory system Blood disorders Multiple myeloma What is multiple myeloma? What are the symptoms? How is it treated? 2.02 Understand the functions and disorders of the circulatory system

Two Types of Circulation Systemic: circulation that carries blood throughout the body Cardiopulmonary: circulation that carries blood from heart to lungs and back 2.01 Remember the structures of the circulatory system