Sirt4: The Glutamine Gatekeeper

Slides:

Advertisements

Similar presentations

Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation Silvia Di Agostino,

Advertisements

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence Carmen Guerra, Manuel Collado, Carolina Navas,

Genetic and Epigenetic Silencing of MicroRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression María J. Bueno, Ignacio Pérez de Castro, Marta Gómez de.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells Nilay Sethi, Xudong Dai, Christopher.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib Ling Li, Lisheng Wang, Liang Li, Zhiqiang.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics Carlos L. Arteaga, Jeffrey A. Engelman Cancer Cell Volume.

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia Tim C.P. Somervaille, Michael L. Cleary Cancer Cell.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle Isabel Beerman, Jun Seita, Matthew A.

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung Zvi Granot, Erik Henke, Elizabeth A. Comen, Tari A. King, Larry Norton, Robert Benezra.

Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.

A Conditional Mouse Model of Synovial Sarcoma: Insights into a Myogenic Origin Malay Haldar, Jeffrey D. Hancock, Cheryl M. Coffin, Stephen L. Lessnick,

The Kinase-Independent, Second Life of CDK6 in Transcription

Charles Swanton, Julian Downward Cancer Cell

NF-κB: A Coordinator for Epigenetic Regulation by MLL

Linking miRNA Regulation to BCR-ABL Expression: The Next Dimension

Volume 1, Issue 1, Pages (June 2007)

Wild-Type RAS: Keeping Mutant RAS in CHK

Yatrik M. Shah, Costas A. Lyssiotis Gastroenterology

HSF1 in Translation Cancer Cell

Mutant p53 gain of function: The NF-Y connection

A Time to Divide: Does the Circadian Clock Control Cell Cycle?

Volume 11, Issue 4, Pages (April 2007)

A Mitochondrial Power Play in Lymphoma

The DNA Damage Response: Ten Years After

RAS unplugged: Negative feedback and oncogene-induced senescence

When Deletions Gain Functions: Commandeering Epigenetic Mechanisms

Oh what a tangled web it weaves: BRCA1 and DNA decatenation

Peter W. Szlosarek, SukJun Lee, Patrick J. Pollard Molecular Cell

MDS Is a Stem Cell Disorder After All

T.S. Karin Eisinger-Mathason, M. Celeste Simon Cancer Cell

Eun-Jung Jung, George A. Calin Cancer Cell

Not All DDRs Are Created Equal: Non-Canonical DNA Damage Responses

CALming Down T Cell Acute Leukemia

You Down With ETC? Yeah, You Know D!

PICS-ure This: Prosenescence Therapy?

Coming up for air: HIF-1 and mitochondrial oxygen consumption

Coordinate Transcriptional Regulation by ERG and Androgen Receptor in Fusion- Positive Prostate Cancers Yu Chen, Charles L. Sawyers Cancer Cell Volume.

When Cancer Cells Are Given Lemo[NH3]s, They Make Lemo[NH3]ade

Cancer Cells Hijack Gluconeogenic Enzymes to Fuel Cell Growth

Richard G. Carroll, Seamus J. Martin Cancer Cell

Cancer Metabolism: Is Glutamine Sweeter than Glucose?

IDH1 Mutations in Gliomas: When an Enzyme Loses Its Grip

Conserved Metabolic Regulatory Functions of Sirtuins

Mitochondria and Cancer

Wissam Assaily, Samuel Benchimol Cancer Cell

LKB1 and Src: Antagonistic Regulators of Tumor Growth and Metastasis

aSIRTing Control over Cancer Stem Cells

Volume 14, Issue 4, Pages (October 2008)

SIRT4 Is a Regulator of Insulin Secretion

Sirt4: The Glutamine Gatekeeper

The DNA Damage Response: Ten Years After

Volume 10, Issue 3, Pages (September 2006)

The TRIP from ULF to ARF Cancer Cell

Volume 32, Issue 1, Pages 3-5 (July 2017)

Ibrutinib Treatment of CLL: The Cancer Fights Back

Volume 12, Issue 6, Pages (December 2007)

Anthony N. Imbalzano, Stephen N. Jones Cancer Cell

Marking Emerging β- and γδ-Selected T Cells

In This Issue Cell Volume 145, Issue 3, (April 2011)

On the Road to Bacterial Cell Death

Proliferating Cells Conserve Nitrogen to Support Growth

Presentation transcript:

Sirt4: The Glutamine Gatekeeper Pablo J. Fernandez-Marcos, Manuel Serrano Cancer Cell Volume 23, Issue 4, Pages 427-428 (April 2013) DOI: 10.1016/j.ccr.2013.04.003 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 SIRT4: The Glutamine Gatekeeper DNA damage (1) elicits the DDR (2) that, through undefined mechanisms (indicated with a question mark), results in enhanced SIRT4 transcription (3) and higher SIRT4 activity in the mitochondria (4). In turn, SIRT4 inhibits glutamine conversion into αKG by inhibiting glutamate dehydrogenase (GDH) (5). Decreased αKG shuts down the anaplerotic replenishment of the tricarboxylic acid cycle (TCA) (6), which, through mechanisms that remain to be clarified (question mark), result in arrest and DNA repair (7). Cancer Cell 2013 23, 427-428DOI: (10.1016/j.ccr.2013.04.003) Copyright © 2013 Elsevier Inc. Terms and Conditions