Part III Lessons Learned: A Master Class in High-Sensitivity Troponin A Global Perspective.

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Presentation transcript:

Part III Lessons Learned: A Master Class in High-Sensitivity Troponin A Global Perspective

Program Goals

Prior Programs in Series

Case: 47-Year-Old Male Homeless Alcoholic Presentation and Medical History

Case Physical Examination Results

Case Chest X-Ray, ECG, and Lab Results

Case Diagnosis and Repeat hs-cTn Testing

ESC Guidelines on the Use of hs-cTn

TRAPID-AMI Protocol for Early Rule-Out/Rule-In of AMI

Serial hs-cTn Measurement Relative vs Absolute Change

hs-cTnT Absolute Δ Change Cutoff for Early Rule-Out of AMI

TRAPID-AMI Rule Out AMI With Single Very Low Baseline hs-cTn and No ECG Ischemia

TRAPID-AMI Rule-In AMI With Single Very High Baseline hs-cTn

Using Lower Risk Score Cutpoints With Contemporary cTn

Comparison of Rule-Out Strategies for AMI Using hs-cTn

Causes of cTn Elevation

APACE Study Design

APACE Duration of Outpatient ED Stay

APACE Use of Coronary Angiographies

APACE Distribution of Coronary Angiography Findings

Effect of Elevated cTn Outside of AMI Outcomes in Patients With AHF in ADHERE

3 Keys to Beating Troponinitis

ADHERE Patients With AHF Have Elevated cTn

Differential Diagnostic Workup

PEARL Renal Function and Scaled Troponin

Case Revisited

Summary of Programs in Series

Abbreviations

Abbreviations (cont)