Genome-wide Association Study Identifies TNFSF15 and POU2AF1 as Susceptibility Loci for Primary Biliary Cirrhosis in the Japanese Population Minoru Nakamura,

Slides:

Advertisements

Similar presentations

Previous Estimates of Mitochondrial DNA Mutation Level Variance Did Not Account for Sampling Error: Comparing the mtDNA Genetic Bottleneck in Mice and.

Advertisements

Alternative Splicing QTLs in European and African Populations Halit Ongen, Emmanouil T. Dermitzakis The American Journal of Human Genetics Volume 97, Issue.

Fragile X and X-Linked Intellectual Disability: Four Decades of Discovery Herbert A. Lubs, Roger E. Stevenson, Charles E. Schwartz The American Journal.

Volume 42, Issue 3, Pages (March 2005)

Volume 68, Issue 4, Pages (April 2018)

Michael Dannemann, Janet Kelso The American Journal of Human Genetics

Volume 152, Issue 6, Pages (May 2017)

Genomic Patterns of Homozygosity in Worldwide Human Populations

Genetic Landscape of Eurasia and “Admixture” in Uyghurs

Volume 68, Issue 4, Pages (April 2018)

Volume 141, Issue 3, Pages e5 (September 2011)

Genome-Wide Association Study Identifies Risk Variants for Lichen Planus in Patients With Hepatitis C Virus Infection Yumiko Nagao, Nao Nishida, Licht.

Volume 125, Issue 5, Pages (November 2003)

Volume 152, Issue 6, Pages (May 2017)

Volume 21, Issue 20, Pages R837-R838 (October 2011)

Incidence and Risk of Postherpetic Neuralgia after Varicella Zoster Virus Infection in Hematopoietic Cell Transplantation Recipients: Hokkaido Hematology.

CHEK2*1100delC and Susceptibility to Breast Cancer: A Collaborative Analysis Involving 10,860 Breast Cancer Cases and 9,065 Controls from 10 Studies

AST/platelet ratio index associates with progression to hepatic failure and correlates with histological fibrosis stage in Japanese patients with primary.

Volume 140, Issue 3, Pages (March 2011)

Volume 139, Issue 4, Pages e3 (October 2010)

Volume 42, Issue 3, Pages (March 2005)

Clinical and Pharmacokinetic Factors Associated With Adalimumab-Induced Mucosal Healing in Patients With Crohn’s Disease Kenji Watanabe, Takayuki Matsumoto,

High-Resolution Genetic Maps Identify Multiple Type 2 Diabetes Loci at Regulatory Hotspots in African Americans and Europeans Winston Lau, Toby Andrew,

Volume 144, Issue 4, Pages (April 2013)

P3.02b-086 ASP8273 Tolerability and Antitumor Activity in TKI-Naïve Japanese Subjects with EGFRmut+ NSCLC: Preliminary Results Makoto Nishio, Koichi.

Variants at HLA-A, HLA-C, and HLA-DQB1 Confer Risk of Psoriasis Vulgaris in Japanese Jun Hirata, Tomomitsu Hirota, Takeshi Ozeki, Masahiro Kanai, Takeaki.

Miao-Xin Li, Hong-Sheng Gui, Johnny S.H. Kwan, Pak C. Sham

Association between Single-Nucleotide Polymorphisms in Selectin Genes and Immunoglobulin A Nephropathy Takashi Takei, Aritoshi Iida, Kosaku Nitta, Toshihiro.

Genetic variations associated with diabetic nephropathy and type II diabetes in a Japanese population S. Maeda, N. Osawa, T. Hayashi, S. Tsukada, M.

Improved Heritability Estimation from Genome-wide SNPs

Genome-wide Association Study Identifies TNFSF15 and POU2AF1 as Susceptibility Loci for Primary Biliary Cirrhosis in the Japanese Population Minoru Nakamura,

10 Years of GWAS Discovery: Biology, Function, and Translation

Michael Dannemann, Janet Kelso The American Journal of Human Genetics

Two Susceptibility Loci to Takayasu Arteritis Reveal a Synergistic Role of the IL12B and HLA-B Regions in a Japanese Population Chikashi Terao, Hajime.

XMCPDT Does Have Correct Type I Error Rates

HYST: A Hybrid Set-Based Test for Genome-wide Association Studies, with Application to Protein-Protein Interaction-Based Association Analysis Miao-Xin.

Japanese Population Structure, Based on SNP Genotypes from 7003 Individuals Compared to Other Ethnic Groups: Effects on Population-Based Association Studies

Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial Kenjiro Kimura, Tatsuo Hosoya, Shunya Uchida, Masaaki.

Random-Effects Model Aimed at Discovering Associations in Meta-Analysis of Genome- wide Association Studies Buhm Han, Eleazar Eskin The American Journal.

Clinical and Pharmacokinetic Factors Associated With Adalimumab-Induced Mucosal Healing in Patients With Crohn’s Disease Kenji Watanabe, Takayuki Matsumoto,

Sang Hong Lee, Naomi R. Wray, Michael E. Goddard, Peter M. Visscher

Structural Architecture of SNP Effects on Complex Traits

A Weighted False Discovery Rate Control Procedure Reveals Alleles at FOXA2 that Influence Fasting Glucose Levels Chao Xing, Jonathan C. Cohen, Eric Boerwinkle

Studying Gene and Gene-Environment Effects of Uncommon and Common Variants on Continuous Traits: A Marker-Set Approach Using Gene-Trait Similarity Regression

Simultaneous Genotype Calling and Haplotype Phasing Improves Genotype Accuracy and Reduces False-Positive Associations for Genome-wide Association Studies

10 Years of GWAS Discovery: Biology, Function, and Translation

Localization of a Gene for Benign Adult Familial Myoclonic Epilepsy to Chromosome 8q23.3-q24.1 Masaaki Mikami, Takeshi Yasuda, Akira Terao, Masayuki.

Five Years of GWAS Discovery

Hugues Aschard, Bjarni J. Vilhjálmsson, Amit D. Joshi, Alkes L

Natural Selection and Population History in the Human Angiotensinogen Gene (AGT): 736 Complete AGT Sequences in Chromosomes from Around the World Toshiaki.

Effectiveness of Gefitinib against Non–Small-Cell Lung Cancer with the Uncommon EGFR Mutations G719X and L861Q Satoshi Watanabe, MD, PhD, Yuji Minegishi,

Shuhua Xu, Wei Huang, Ji Qian, Li Jin

Erratum The American Journal of Human Genetics

Multiplexed Molecular Profiling of Lung Cancer Using Pleural Effusion

Benjamin A. Rybicki, Robert C. Elston

A Unified Approach to Genotype Imputation and Haplotype-Phase Inference for Large Data Sets of Trios and Unrelated Individuals Brian L. Browning, Sharon.

Huwenbo Shi, Gleb Kichaev, Bogdan Pasaniuc

Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis Yukinori Okada, Akari Suzuki, Katsunori Ikari, Chikashi Terao,

Joseph K. Pickrell The American Journal of Human Genetics

Association of the Gene Encoding Wingless-Type Mammary Tumor Virus Integration- Site Family Member 5B (WNT5B) with Type 2 Diabetes Akio Kanazawa, Syuuichi.

L-GATOR: Genetic Association Testing for a Longitudinally Measured Quantitative Trait in Samples with Related Individuals Xiaowei Wu, Mary Sara McPeek

Interpretation of Association Signals and Identification of Causal Variants from Genome- wide Association Studies Kai Wang, Samuel P. Dickson, Catherine.

A potential of autologous pericardium for a sustained-release carrier of vancomycin: A pilot study in vitro Akira Marui, MD, PhD, Keiichi Hirose, MD,

Xiang Wan, Can Yang, Qiang Yang, Hong Xue, Xiaodan Fan, Nelson L. S

Genomewide Association Analysis of Human Narcolepsy and a New Resistance Gene Minae Kawashima, Gen Tamiya, Akira Oka, Hirohiko Hohjoh, Takeo Juji, Takashi.

Gastrointestinal Endoscopy

Harold A. Nieuwboer, René Pool, Conor V. Dolan, Dorret I

Leveraging Multi-ethnic Evidence for Mapping Complex Traits in Minority Populations: An Empirical Bayes Approach Marc A. Coram, Sophie I. Candille, Qing.

Risk Prediction of Complex Diseases from Family History and Known Susceptibility Loci, with Applications for Cancer Screening Hon-Cheong So, Johnny S.H.

Zuoheng Wang, Mary Sara McPeek The American Journal of Human Genetics

Presentation transcript:

Genome-wide Association Study Identifies TNFSF15 and POU2AF1 as Susceptibility Loci for Primary Biliary Cirrhosis in the Japanese Population Minoru Nakamura, Nao Nishida, Minae Kawashima, Yoshihiro Aiba, Atsushi Tanaka, Michio Yasunami, Hitomi Nakamura, Atsumasai Komori, Makoto Nakamuta, Mikio Zeniya, Etsuko Hashimoto, Hiromasa Ohira, Kazuhide Yamamoto, Morikazu Onji, Shuichi Kaneko, Masao Honda, Satoshi Yamagiwa, Kazuhiko Nakao, Takafumi Ichida, Hajime Takikawa, Masataka Seike, Takeji Umemura, Yoshiyuki Ueno, Shotaro Sakisaka, Kentaro Kikuchi, Hirotoshi Ebinuma, Noriyo Yamashiki, Sumito Tamura, Yasuhiko Sugawara, Akira Mori, Shintaro Yagi, Ken Shirabe, Akinobu Taketomi, Kuniaki Arai, Kyoko Monoe, Tatsuki Ichikawa, Makiko Taniai, Yasuhiro Miyake, Teru Kumagi, Masanori Abe, Kaname Yoshizawa, Satoru Joshita, Shinji Shimoda, Koichi Honda, Hiroki Takahashi, Katsuji Hirano, Yasuaki Takeyama, Kenichi Harada, Kiyoshi Migita, Masahiro Ito, Hiroshi Yatsuhashi, Nobuyoshi Fukushima, Hajime Ota, Tatsuji Komatsu, Takeo Saoshiro, Jinya Ishida, Hirotsugu Kouno, Hirotaka Kouno, Michiyasu Yagura, Masakazu Kobayashi, Toyokichi Muro, Naohiko Masaki, Keiichi Hirata, Yukio Watanabe, Yoko Nakamura, Masaaki Shimada, Noboru Hirashima, Toshiki Komeda, Kazuhiro Sugi, Michiaki Koga, Keisuke Ario, Eiichi Takesaki, Yoshihiko Maehara, Shinji Uemoto, Norihiro Kokudo, Hirohito Tsubouchi, Masashi Mizokami, Yasuni Nakanuma, Katsushi Tokunaga, Hiromi Ishibashi The American Journal of Human Genetics Volume 91, Issue 4, Pages 721-728 (October 2012) DOI: 10.1016/j.ajhg.2012.08.010 Copyright © 2012 The American Society of Human Genetics Terms and Conditions

Figure 1 GWAS Results From 963 samples (487 Japanese PBC cases and 476 Japanese healthy controls), p values were calculated with a chi-square test for allele frequencies among 420,928 SNPs. The American Journal of Human Genetics 2012 91, 721-728DOI: (10.1016/j.ajhg.2012.08.010) Copyright © 2012 The American Society of Human Genetics Terms and Conditions

Figure 2 LD Structure, p Values, and OR Plots in the Association Analysis LD maps (A) around TNFSF15 (chr9: nucleotide position: 116561403–116733452; build 36.3) and (B) around POU2AF1 (chr11: nucleotide position: 110684600–110802128; build 36.3). The middle panels show estimates of pairwise r2 for (A) 28 SNPs and (B) 33 SNPs in the high-density mapping with a total of 2,365 samples used. The bottom panels show p values and OR-based chi-square tests for the allelic model for the left panels of 963 samples in the GWAS (●), the right panels of 1,402 samples in the replication study (▴), and the combined analysis (⋄). The American Journal of Human Genetics 2012 91, 721-728DOI: (10.1016/j.ajhg.2012.08.010) Copyright © 2012 The American Society of Human Genetics Terms and Conditions