Quiz 3 review | September 21, 2016

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Quiz 3 review | September 21, 2016

Quiz 3 Review Autoimmune diseases Immunodeficiencies Transfusion Transplantation

Quiz 3 Review Autoimmune diseases

Lupus Things You Must Know Typical patient: young woman with butterfly rash Symptoms unpredictable (relapsing/remitting) Multisystem (skin, kidneys, joints, heart) Antinuclear antibodies

Lupus: butterfly rash

Rheumatoid Arthritis Things You Must Know Symmetric, mostly small-joint arthritis Systemic symptoms (skin, heart, vessels, lungs) Rheumatoid factor Cytokines (especially TNF) cause damage

Rheumatoid arthritis joint deformities

Sjögren Syndrome Things You Must Know Inflammatory disease of salivary and lacrimal glands Dry eyes, dry mouth T cells react against some Ag in gland; gland gets destroyed Increased risk of lymphoma

Sjögren syndrome: salivary gland enlargement

Scleroderma (Systemic Sclerosis) Things You Must Know Excessive fibrosis throughout body: skin, viscera Claw hands, mask-like face Microvascular disease also present Diffuse and limited types

Systemic sclerosis: claw hands

Quiz 3 Review Autoimmune diseases Immunodeficiencies

Immune Diseases Outline Transmission Defect Clinical stuff XLA X-linked No mature B cells; no Ig Infant with recurrent bacterial infections CVID non x-linked Defective Ab production Infections, AI diseases, lymphoma IgA deficiency ↓ IgA Most common. Asx. AI diseases Hyper-IgM ↓ IgG, A, E T cell defect Bacterial and fungal infections DiGeorge No thymus Viral, fungal infections SCID half are x-linked Many B and T cell defects Bacterial and other infections

Quiz 3 Review Autoimmune diseases Immunodeficiencies Transfusion

Genotype Antigens Blood type AA A AO BB B BO AB A and B OO None O

Genotype Antigens Blood type DD D Rh + Dd dd none Rh -

What can go wrong? Transfusion reactions hemolytic non-hemolytic Other complications infections iron overload

Quiz 3 Review Autoimmune diseases Immunodeficiencies Transfusion Transplantation

HLA genes are inherited as sets (haplotypes) ♂ ♀ parents four possible haplotype combinations in children

HLA genes are polymorphic ♂ ♀ A B C DR DQ DP 1 7 w3 2 1 1 Dad’s HLA genes 2 8 w2 3 2 2 3 44 w4 4 1 3 Mom’s HLA genes 11 35 w1 7 3 4

HLA genes are codominantly expressed

time after transplant, months 100 number of mismatches Class I Class II 1 or 2 3 or 4 graft survival, % 50 3 6 12 time after transplant, months