Consort Diagram 600 pts with 644 eyes accessed for eligibility

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Presentation transcript:

Consort Diagram 600 pts with 644 eyes accessed for eligibility 86 pts with 130 eyes excluded 514 pts included in study each contributing 1 eye 44 bilateral pts with each eye group D or E 32 pts received extensive pre-enucleation treatment 2 pts died from chemo toxicity 3 pts received pre-enucleation chemo for less than one complete cycle 3 pts had non-tumor enucleation 2 pts abandoned treatment after tumor recurrence 1 atrophy w/o chemo 2 vitreous hemorrhage 174 D eyes 340 E eyes 3 plaque 6 PPV 1 stem cell 18 IAC 3 radio Factors to consider: pathologic staging, time from diagnosis to enu, neoadjuvant chemo, adjuvant chemo Dependent variable: mortality. 1 immunotherapy

Relationship between neoadjuvant chemo cycle and pathology for staged D&E Eyes Low Risk Pathology (LRP): pT1 and pT2 High Risk Pathology (HRP): pT3 and pT4

Relationship between neoadjuvant chemo cycle and mortality After Controlling for Adjuvant Chemo (Kaplan Mier Survival Analysis)