GRAM POSITIVE COCCI Gram positive and negative bacteria:

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Presentation transcript:

GRAM POSITIVE COCCI Gram positive and negative bacteria: The cell wall very different: . Peptidoglycanvery strong, thick and rigid. . Teichoic acid surface antigen.

Species cause of human disease: Staphylococcus aureus Streptococcus pneumoniae Streptococcus pyogenic ect

Structure and function Capsule antiphagocytosis Peptidoglycan stimulate production of endogenous pyrogens Protein spesific:A,M,F antiphagocytosis,anticomplementary Teichoic acid attachment to mucosal

Pathogenesis and Immunity The virulence is determined by: a variety of structural molecule and elaborated toxins and enzymes.  virulence factors

Toxins - Exotoxin : 1. Cytotoxin 2. Enterotoxin food poisoning .resistant to gastric &jejunal enzymes. .heat stable .stimulate intestinal peristalsis

Enzymes . Coagulase  fibrin layer . Catalase  H2O2 . Hyaluronidase  spreading factors . Lipase . Fibrinolysin . Penicillinase . Ig A protease . Hemolysin : Streptolysin O  antigenic

Important features of pathogenesis Staphylococcus aureus 1. Pyogenic (abscess) - local  skin infection surgical wound infection - disseminated  sepsis 2. Toxigenic  food poisoning

Staphylococcus epidermidis Pyogenic  iv catheter sites & prostetic devices Staphylococcus saprophyticus Pyogenic  UTI(Urinary Tract Infection )

Streptococcus pyogenes 1.Pyogenic . Local : skin,pharing . Disseminated : sepsis 2. Toxigenic 3. Immune-mediated(post Streptococcal infection,non suppurative)

Poststreptococcal disease Immunologic response to streptococcal M protein that cross-react with human tissues. Acute Glomerulonephritis antigen-antibody complexes on glomerular. Acute Rheumatic Fever autoimmune disease

Streptococcus pneumoniae Pyogenic : . Pneumonia . Otitis media . Meningitis