The cBio Cancer Genomics Portal.

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Presentation transcript:

The cBio Cancer Genomics Portal. The cBio Cancer Genomics Portal. A, the cBio Cancer Genomics Portal is an open platform for interactively exploring multidimensional cancer genomics data sets in the context of clinical data and biologic pathways. B, OncoPrint of RB pathway alterations in GBM. Genomic alterations of different members in the RB pathway are mutually exclusive. The OncoPrint provides an overview of genomic alterations (legend) in particular genes (rows) affecting particular individual samples (columns). C, mutation details for RB1. The predicted functional impact of the RB1 missense mutations in GBM can be assessed through Mutation Assessor. This includes a predicted functional impact score, a multiple sequence alignment of different family members, and a 3-dimensional structure view, when available. D, correlation plot for CDK4. GBM samples with CDK4 amplification have markedly increased CDK4 mRNA expression. E, survival analysis. GBM cases with an RB pathway alteration have worse overall survival than cases without an RB pathway alteration. F, network view of the BRCA1/BRCA2 neighborhood in serous ovarian cancer. BRCA1 and BRCA2 are seed genes (indicated with thick border), and all other genes are automatically identified as altered in ovarian cancer. Multidimensional genomic details are shown for BRCA2 and C11orf30/EMSY. Darker red indicates increased frequency of alteration (defined by mutation, copy number amplification, or homozygous deletion) in ovarian cancer. G, distribution of BRCA1 mutations in ovarian cancer across protein domains. The 2 hot spots (p.E23fs and p.Q1756fs) represent the common founder mutations 185delAG and 5382insC frequently observed in BRCA1. Ethan Cerami et al. Cancer Discovery 2012;2:401-404 ©2012 by American Association for Cancer Research