Parkinson’s progression markers initiative PPMI 2018 ANNUUAL INVESTIGATORS MEETING

PPMI Status Update

PPMI SITES IN AUSTRALIA: PPMI SITES IN THE UNITED STATES: Arizona PD Consortium (Sun City, AZ) Beth Israel Medical Center (NY, NY) Baylor College of Medicine (Houston, TX) Boston University (Boston, MA) Cleveland Clinic (Cleveland, OH) Columbia University (NY, NY) Emory University (Atlanta, GA) Institute of Neurodegenerative Disorders (New Haven, CT) Johns Hopkins University (Baltimore ,MD) Northwestern University (Chicago, IL) Oregon Health and Science University (Portland, OR) The Parkinson’s Institute (Sunnyvale, CA) PD & Movement Disorders Center at Boca Raton (Boca Raton, FL) University of Alabama at Birmingham (Birmingham, AL) University of California at San Diego (San Diego, CA) University of California San Francisco (San Francisco, CA) University of Cincinnati (Cincinnati, OH) University of Pennsylvania (Philadelphia, PA) University of Rochester (Rochester, NY) University of South Florida (Tampa, FL) University of Washington (Seattle, WA) PPMI SITES IN EUROPE: Foundation for Biomedical Research of the Academy of Athens (Athens, Greece) Imperial College (London, UK) Innsbruck University (Innsbruck, Austria) Norwegian University of Science and Technology (Trondheim, Norway) Paracelsus-Elena Clinic Kassel/University of Marburg (Kassel and Marburg, Germany) Pitié-Salpêtrière Hospital (Paris, France) University of Barcelona (Barcelona, Spain) University of Donostia (San Sebastien, Spain) University of Salerno (Salerno, Italy) University of Tübingen (Tübingen, Germany) Kings College London (London, UK) PPMI SITES IN AUSTRALIA: Macquarie University (Sydney, Australia) PPMI SITES IN Israel: Tel Aviv Sourasky Medical Center (Tel Aviv, Israel)

Enrollment, retention and compliance

OVERVIEW Source of data for this presentation: Information comes from: Tables produced for CSOC report Tables produced for monthly review by steering committee Additional data requests All data comes from a data freeze based on data obtained from the LONI website on 04/02/2018.

PPMI ENROLLMENT - 2018 GROUP Consented Enrolled Withdrawn Active Completed PD Subjects 489 423 72 337 14 Healthy Controls 241 196 31 158 7 SWEDD Subjects 81 64 10 3 51 Prodromal - Hyposmic 119 26 4 22 Prodromal-RBD 96 39 36 LRRK2 PD Cohort 155 141 6 135 LRRK2 UA Cohort 190 180 SNCA PD Cohort 19 1 18 SNCA UA Cohort GBA PD Cohort 77 73 70 GBA UA Cohort 129 126 TOTAL 1615 1306 143 1091

GENETIC COHORTS ENROLLMENT

VISIT COMPLIANCE - 2018 Group 6 Months # Exp (% Comp) 1 Year # Exp (% Comp) 2 Year # Exp (% Comp) 3 Year # Exp (% Comp) 4 Year # Exp (% Comp) 5 Year # Exp (% Comp) PD 414 (95%) 409 (96%) 399 (95%) 388 (94%) 377 (92%) 308 (87%) HC 192 (95%) 189 (98%) 181 (96%) 176 (95%) 172 (94%) 153 (88%) SWEDD 62 (89%) 62 (94%) 61 (90%) 3 (33%) 3 (67%) 3 (100%) Hyposmic 25 (96%) 24 (100%) 24 (96%) 20 (90%) N/A RBD 38 (97%) 38 (95%) 33 (91%) 4 (100%) Genetic PD 205 (89%) 173 (90%) 115 (79%) 68 (87%) 2 (100%) Genetic UA 250 (88%) 196 (93%) 84 (93%) 44 (84%) 6 (50%) Number Expected = Number of active subjects within the milestone window % Completed = Number of active subjects that completed the assessment within the milestone window

LUMBAR PUNCTURE COMPLETENESS Group Baseline # Exp (% Comp) 6 Months # Exp (% Comp) 1 Year #Exp (% Comp) 2 Year #Exp (% Comp) 3 Year #Exp (% Comp) 4 Year #Exp (% Comp) 5 Year #Exp (% Comp) PD 423 (98%) 392 (88%) 392 (84%) 378 (82%) 365 (78%) 346 (69%) 269 (62%) HC 196 (97%) 183 (87%) 185 (84%) 174 (79%) 167 (78%) 162 (67%) 135 (68%) SWEDD 64 (92%) 55 (85%) 58 (83%) 55 (71%) N/A Hyposmic 23 (87%) 21 (76%) 21 (81%) 20 (60%) 17 (71%) 3 (67%) RBD 38 (92%) 37 (81%) 37 (78%) 36 (67%) 30 (70%) 4 (25%) Genetic PD 226 (84%) 155 (60%) 91 (65%) 59 (58%) 2 (100%) Genetic UA 324 (88%) 182 (75%) 78 (68%) 37 (73%) Number Expected = Number of active subjects with completed visit % Completed = Number of active subjects that completed the assessment when they completed the visit

DATSCAN COMPLETENESS Group Baseline # Expected (% Comp) 1 Year #Expected (% Comp) 2 Year #Expected (% Comp) 4 Year #Expected (% Comp) PD 423 (99%) 392 (96%) 378 (93%) 346 (85%) HC 196 (91%) N/A SWEDD 64 (97%) 55 (96%) Hyposmic 26 (100%) 24 (88%) 23 (91%) RBD 39 (100%) 37 (97%) 36 (100%) Genetic PD 231 (84%) 91 (81%) 2 (100%) Genetic UA 324 (94%) 78 (87%) 3 (67%) Number Expected = Number of active subjects with completed visit % Completed = Number of active subjects that completed the assessment when they completed the visit

TIME TO START PD MEDS