Dipeptidyl peptidase IV deficiency increases susceptibility to angiotensin-converting enzyme inhibitor–induced peritracheal edema  James Brian Byrd, MD, Ajai Shreevatsa, MD, Pradeep Putlur, MD, Denis Foretia, BS, Laurie McAlexander, Tuhin Sinha, PhD, Mark D. Does, PhD, Nancy J. Brown, MD  Journal of Allergy and Clinical Immunology  Volume 120, Issue 2, Pages 403-408 (August 2007) DOI: 10.1016/j.jaci.2007.04.012 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 DPPIV activity in DPPIV− rats from Japan and DPPIV+ rats from a domestic source. ∗P < .001 versus DPPIV− rats. Journal of Allergy and Clinical Immunology 2007 120, 403-408DOI: (10.1016/j.jaci.2007.04.012) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 The anatomy scanned in the MRI studies. A shows a scout MRI scan in the sagittal view. Blue lines indicate the position of the 24 MRI slices. For comparison, B shows a sagittal cryosection through a rat in the same region. Cryosection image from the SD Rat Atlas Project (http://vchibp.vicp.net/vch/mice/) is used with permission. Journal of Allergy and Clinical Immunology 2007 120, 403-408DOI: (10.1016/j.jaci.2007.04.012) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 T2-weighted MRI image and corresponding line drawing of vocal cords at baseline (A and C) and at 50 minutes (B and D) after injection of captopril in a DPPIV− rat. Fig 3, B and D, show the development of vocal cord edema. The red asterisks illustrate the airway at the level of the vocal cords in these transverse slices. Journal of Allergy and Clinical Immunology 2007 120, 403-408DOI: (10.1016/j.jaci.2007.04.012) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Effect of captopril on tracheal edema in DPPIV− and DPPIV+ rats. Edema formation was significantly greater in captopril-treated DPPIV− rats than in any other treatment group (see text). Journal of Allergy and Clinical Immunology 2007 120, 403-408DOI: (10.1016/j.jaci.2007.04.012) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Effect of treatment on blood pressure in DPPIV+ and DPPIV− rats. MAP was significantly less in captopril plus thiorphan–treated DPPIV− rats compared with that in saline-treated DPPIV− rats (P = .01) or captopril plus thiorphan–treated DPPIV+ rats (P = .045). Spantide significantly increased MAP in captopril plus thiorphan–treated DPPIV− rats (P = .03). Journal of Allergy and Clinical Immunology 2007 120, 403-408DOI: (10.1016/j.jaci.2007.04.012) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions