Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet by Hartmut Döhner, Elihu H. Estey, Sergio Amadori, Frederick R. Appelbaum, Thomas Büchner, Alan K. Burnett, Hervé Dombret, Pierre Fenaux, David Grimwade, Richard A. Larson, Francesco Lo-Coco, Tomoki Naoe, Dietger Niederwieser, Gert J. Ossenkoppele, Miguel A. Sanz, Jorge Sierra, Martin S. Tallman, Bob Löwenberg, and Clara D. Bloomfield Blood Volume 115(3):453-474 January 21, 2010 ©2010 by American Society of Hematology

Pie chart illustrating the molecular heterogeneity of cytogenetically normal AML based on mutations in the NPM1, CEBPA, MLL, FLT3 (ITD and TKD mutations at codons D835 and I836), NRAS, and WT1 genes. Pie chart illustrating the molecular heterogeneity of cytogenetically normal AML based on mutations in the NPM1, CEBPA, MLL, FLT3 (ITD and TKD mutations at codons D835 and I836), NRAS, and WT1 genes. The bluish colors denote NPM1-mutated subsets, the orange/red colors CEBPA-mutated subsets, and the yellow/green colors MLL-mutated subsets. The gray colors depict subsets without hypothetical class II mutations, and the white sector shows the subset without any mutation in the above-mentioned genes. Data are derived from mutational analysis of 485 younger adult patients with cytogenetically normal AML from AMLSG. Hartmut Döhner et al. Blood 2010;115:453-474 ©2010 by American Society of Hematology