Determination of vhl Gene Mutations in Sporadic Renal Cell Carcinoma

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Presentation transcript:

Determination of vhl Gene Mutations in Sporadic Renal Cell Carcinoma José Miguel Giménez-Bachs, Antonio S. Salinas-Sánchez, Francisco Sánchez-Sánchez, Juan G. Lorenzo-Romero, María José Donate- Moreno, Héctor Pastor-Navarro, Dolores C. García-Olmo, Julio Escribano-Martínez, Julio A. Virseda-Rodríguez European Urology Volume 49, Issue 6, Pages 1051-1057 (June 2006) DOI: 10.1016/j.eururo.2005.10.028 Copyright © 2005 Elsevier B.V. Terms and Conditions

Fig. 1 Amplification conditions for the different exons. European Urology 2006 49, 1051-1057DOI: (10.1016/j.eururo.2005.10.028) Copyright © 2005 Elsevier B.V. Terms and Conditions

Fig. 2 Electrophoretogram showing a mutation in exon 2. European Urology 2006 49, 1051-1057DOI: (10.1016/j.eururo.2005.10.028) Copyright © 2005 Elsevier B.V. Terms and Conditions

Fig. 3 Comparison of several mutated amino acids to those of the protein in various animal species. The sequences of three animal species in addition to humans are shown. The mutations found in this study and the conservation status of the mutated amino acids in these species are indicated in red; most can be seen to be conserved, providing some idea of the functional importance of these amino acids in the protein. European Urology 2006 49, 1051-1057DOI: (10.1016/j.eururo.2005.10.028) Copyright © 2005 Elsevier B.V. Terms and Conditions