Is Ductal Carcinoma In Situ With “Possible Invasion” More Predictive of Invasive Carcinoma Than Pure Ductal Carcinoma In Situ? Tal Arazi-Kleinman, MD,

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Is Ductal Carcinoma In Situ With “Possible Invasion” More Predictive of Invasive Carcinoma Than Pure Ductal Carcinoma In Situ? Tal Arazi-Kleinman, MD, Petrina A. Causer, MD, Sharon Nofech-Mozes, MD, Roberta A. Jong, MD Canadian Association of Radiologists Journal Volume 63, Issue 2, Pages 146-152 (May 2012) DOI: 10.1016/j.carj.2010.10.002 Copyright © 2012 Canadian Association of Radiologists Terms and Conditions

Figure 1 Mammographic and pathologic findings in a 65-year-old woman with prior right mastectomy. (A) Left mediolateral oblique and (B) Craniocaudate views demonstrate a new cluster of microcalcifications in the central upper left breast, without an associated mass (circle). (C) Lateral and (D) caudocranial spot compression magnification views characterize the calcifications as pleomorphic. (E) Low-power photomicrograph (hematoxylin and eosin stain), showing high-grade ductal carcinoma in situ (DCIS), solid type (arrow heads), diagnosed by stereotactic 14-gauge core needle biopsy. A small group of malignant cells are noted in the stroma (arrow) and appear to lack myoepithelial cells at its periphery (high-power photomicrograph insert). This focus does not appear on a deeper level, thus, immunohistochemistry to demonstrate the lack of myoepithelial cells and confirm stromal invasion is not feasible in this case. As a result, the lesion was designated as DCIS with possible invasion. Subsequent resection yielded a focus of 1 cm of invasive ductal carcinoma. This figure is available in colour online at http://carjonline.org/. Canadian Association of Radiologists Journal 2012 63, 146-152DOI: (10.1016/j.carj.2010.10.002) Copyright © 2012 Canadian Association of Radiologists Terms and Conditions