Mohan Manu T, T. Anand, Farhath Khanum Pathophysiology

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Attenuation of cytotoxicity induced by tBHP in H9C2 cells by Bacopa monniera and Bacoside A Mohan Manu T, T. Anand, Farhath Khanum Pathophysiology Volume 25, Issue 2, Pages 143-149 (June 2018) DOI: 10.1016/j.pathophys.2018.03.002 Copyright © 2018 Elsevier B.V. Terms and Conditions

Pathophysiology 2018 25, 143-149DOI: (10.1016/j.pathophys.2018.03.002) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 1 (A) Dose-dependent effects of tBHP (0–275 μM) on H9C2 cell viability. (B) Dose dependent protective effect of BME (0–150 μg/ml) on tBHP (150 μM) induced cytotoxicity. (C) Dose dependent protective effect of Bacoside A (0–10 μg/ml) on tBHP (150 μM concentration) induced cytotoxicity. The data represented as mean ± SEM of three independent experiments. *p < 0.05 versus control group. Pathophysiology 2018 25, 143-149DOI: (10.1016/j.pathophys.2018.03.002) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 2 (A) Dose-dependent effects of tBHP (0–250 μM) on LDH leakage. (B) Protective effect of BME (125 μg/ml) and Bacoside-A (6 μg/ml) on tBHP (150 μM) induced LDH leakage. The data represented as mean ± SEM of three independent experiments. *p < 0.05 versus control group and #p < 0.05 versus tBHP treated group. Pathophysiology 2018 25, 143-149DOI: (10.1016/j.pathophys.2018.03.002) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 3 (A) Estimation of ROS production induced by tBHP in H9C2 cells. (B) Protective effect of BME (125 μg/ml) and Bacoside A (6 μg/ml) on tBHP (150 μM) induced lipid peroxidation in H9C2 cells. The data represented as mean ± SEM of three independent experiments. *p < 0.05 versus control group and #p < 0.05 versus tBHP treated group. Pathophysiology 2018 25, 143-149DOI: (10.1016/j.pathophys.2018.03.002) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 4 (A) Effect of BME (125 μg/ml) and Bacoside-A (6 μg/ml) on tBHP (150 μM concentration) induced mitochondrial membrane potential. (B) Effect of BME (125 μg/ml) and Bacoside-A (6 μg/ml) on tBHP (150 μM) induced decrease of nitrite levels. The data represented as mean ± SEM of three independent experiments. *p < 0.05 versus control group and #p < 0.05 versus tBHP treated group. Pathophysiology 2018 25, 143-149DOI: (10.1016/j.pathophys.2018.03.002) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 5 (A) Protective effect of BME (125 μg/ml) and Bac-A (6 μg/ml) against t-BHP treatment on expression of apoptotic marker proteins Bcl2, Bax and iNOS. (B) The band intensity is calculated by NIH Image J software. The data represented as mean ± SEM of three independent experiments. *p < 0.05 versus control group and #p < 0.05 versus tBHP treated group. Pathophysiology 2018 25, 143-149DOI: (10.1016/j.pathophys.2018.03.002) Copyright © 2018 Elsevier B.V. Terms and Conditions