S. Arenas-Lopez, H. Mulla, S. Manna, A. Durward, I. A. Murdoch, S. M

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Presentation transcript:

Enteral absorption and haemodynamic response of clonidine in infants post-cardiac surgery S. Arenas-Lopez, H. Mulla, S. Manna, A. Durward, I.A. Murdoch, S.M. Tibby British Journal of Anaesthesia Volume 113, Issue 6, Pages 964-969 (December 2014) DOI: 10.1093/bja/aeu258 Copyright © 2014 The Author(s) Terms and Conditions

Fig 1 Enteral absorption profiles for all patients. The dashed horizontal line represents a plasma concentration of 0.3 ng ml−1, which is the desired minimum therapeutic concentration at which sedative effects are seen. British Journal of Anaesthesia 2014 113, 964-969DOI: (10.1093/bja/aeu258) Copyright © 2014 The Author(s) Terms and Conditions

Fig 2 Relationship between time to maximum plasma concentration of clonidine (Tmax) and cumulative morphine dose. An interaction is seen with the use of the phosphodiesterase 3 inhibitor, milrinone. Regression lines are shown with shaded areas representing 95% confidence intervals. British Journal of Anaesthesia 2014 113, 964-969DOI: (10.1093/bja/aeu258) Copyright © 2014 The Author(s) Terms and Conditions

Fig 3 Haemodynamic effects after clonidine administration. CVP, central venous pressure; LAP, left atrial pressure; AP, arterial pressure. Symbols represent mean values; error bars are sem. British Journal of Anaesthesia 2014 113, 964-969DOI: (10.1093/bja/aeu258) Copyright © 2014 The Author(s) Terms and Conditions

Fig 4 Prediction-corrected visual predictive check of model performance based on n=1000 replicates. The figure utilizes combined data from the current and previous studies.14 See Supplementary material for further explanation. British Journal of Anaesthesia 2014 113, 964-969DOI: (10.1093/bja/aeu258) Copyright © 2014 The Author(s) Terms and Conditions

Fig 5 Comparison of simulated plasma clonidine concentrations vs time for a 1-yr-old infant after a single dose of 3 μg kg−1 clonidine using absorption profiles derived from our and Larsson and colleagues'13 studies. British Journal of Anaesthesia 2014 113, 964-969DOI: (10.1093/bja/aeu258) Copyright © 2014 The Author(s) Terms and Conditions