Patterning Spinal Motor Activity in the Absence of Synaptic Excitation

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Patterning Spinal Motor Activity in the Absence of Synaptic Excitation Steven A. Crone, Kamal Sharma Neuron Volume 71, Issue 6, Pages 957-959 (September 2011) DOI: 10.1016/j.neuron.2011.09.004 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 The Miller-Scott Model Circuit in Wild-Type and vGluT2 Knockout Mice (A) The Miller-Scott model circuit (redrawn, based on Miller and Scott, 1977). Schematic of excitatory (glutamatergic, cholinergic) inputs and inhibitory (GABA or glycine) inputs between motor neurons (MN), Renshaw cells (RC), and Ia inhibitory interneurons (Ia-IN) in spinal segments controlling flexion (F) and extension (E). Motor activity can be initiated by glutamatergic input from reticulospinal (RS) pathways or by Ia sensory afferents (Ia). This circuit is designed to ensure alternation of flexor and extensor motor neurons during locomotion. (B) Elements of the Miller-Scott model circuit preserved in mice lacking vGluT2. Neuron 2011 71, 957-959DOI: (10.1016/j.neuron.2011.09.004) Copyright © 2011 Elsevier Inc. Terms and Conditions