SWAG SSG Skin Cancer Meeting Tuesday 22nd May Research Report

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SWAG SSG Skin Cancer Meeting Tuesday 22nd May Research Report Clinical Research Network West of England SWAG SSG Skin Cancer Meeting Tuesday 22nd May Research Report

Clinical Research Network & Cancer Services West ofEngland SWAG - Somerset Wiltshire Avon & Gloucestershire South West Children’s Cancer & Leukaemia Research Network

NIHR CRN High Level Objectives 2017-18 Increase number of participants into NIHR CRN portfolio studies 650,000 in England 21,905 in West of England Increase the number of studies that deliver to time and target Target 80% Increase number of commercial studies delivered through network Reduce NHS study set up times Reduce time taken to recruit first participant

Cancer specialty objective for 2017-18 Number of LCRNs achieving on-target recruitment into at least 8 of the 13 Cancer subspecialties, where "on-target" means either improving recruitment by 10% from 2016/17 or meeting the following recruitment targets per 100,000 population served:  a) Brain & CNS: 0.2; b) Breast: 8; c) Colorectal: 3; d) Paediatrics: 3; e) Gynae: 3; f) Head & Neck: 1; g) Haematology: 7; h) Lung: 4; i) Sarcoma: 0.1; j) Skin: 0.2; k) Supportive & Palliative Care and Psychosocial Oncology & Survivorship: 3; l) Upper GI: 3; m) Urology: 8.

Performance regarding 2017/18 Cancer specialty target

Open studies - Lung CPMS ID Title Edge end date Recruited (total) Target Edge recruitment end date CPMS recruitment end date Principle investigator Link to study details 9851 LungCAST - Does smoking status after a diagnosis of lung cancer affect outcomes? Gloucestershire Hospitals NHS Foundation Trust 50 24 31/03/2019 30/06/2021 Raghuran, Dr Ananthakrishnan http://public-odp.nihr.ac.uk/9851 Great Western Hospitals NHS Foundation Trust 1 25 Khan, Dr Omar North Bristol NHS Trust 12 20 21/03/2019 Comins, Dr Charles 15909 MARS 2 2 30/09/2020 31/07/2020 Maskell, Dr Nick http://public-odp.nihr.ac.uk/15909 30083 CANC 5371 3 31/01/2019 31/03/2020 -

Open studies - Lung CPMS ID Title Partner organisation Target Recruited (total) Edge recruitment end date CPMS recruitment end date Principle investigator Link to study details 31643 MesoTRAP feasibility study North Bristol NHS Trust 1 2 30/09/2019 30/06/2019 Maskell, Dr Nick http://public-odp.nihr.ac.uk/31643 5686 Lung ART University Hospitals Bristol NHS Foundation Trust 15 01/05/2018 25/10/2018 Comins, Dr Charles http://public-odp.nihr.ac.uk/5686 18341 The VIOLET study 174 67 31/03/2019 30/04/2019 Batchelor, Tim http://public-odp.nihr.ac.uk/18341 20184 SARON 6 01/03/2019 http://public-odp.nihr.ac.uk/20184 31018 ATLANTIS Trial 3 31/03/2018 31/07/2018 Dangoor, Dr Adam -

Studies open - Lung CPMS ID Title Partner organisation Target Recruited (total) Edge recruitment end date CPMS recruitment end date Principle investigator Link to study details 36310 Adjuvant canakinumab vs placebo in stages IB, II-IIIA resected NSCLC University Hospitals Bristol NHS Foundation Trust 8 31/08/2020 31/05/2020 Ayre, Dr Gareth -

Studies in set-up – Lung CPMS ID Title Partner organisation Link to study details 15909 MARS 2 University Hospitals Bristol NHS Foundation Trust http://public-odp.nihr.ac.uk/15909 17746 National Lung Matrix: Multi-Drug Phase II trial in NSC Lung Cancer http://public-odp.nihr.ac.uk/17746 32033 ROVA-T Maintenance in SCLC (MERU) Gloucestershire Hospitals NHS Foundation Trust - 32290 CONFIRM http://public-odp.nihr.ac.uk/32290 36310 Adjuvant canakinumab vs placebo in stages IB, II-IIIA resected NSCLC

Studies open to new sites - Lung CPMS ID Title Lead LCRN Link to study summary Contact 19914 LuCID: Lung Cancer Indicator Detection North Thames http://public-odp.nihr.ac.uk/19914 Jessica.bartlett@nihr.ac.uk 31183 Investigation of biological changes in urine in patients with advanced lung cancer: a pilot study North West Coast http://public-odp.nihr.ac.uk/31183 31692 Study 15 http://public-odp.nihr.ac.uk/31692 31920 Deciphering Antitumour Response and Resistance With INtratumour Heterogeneity A phase II, multi-centre, non-randomised, molecularly stratified trial for NSCLC patients to study tumour heterogeneity using genomic analysis http://public-odp.nihr.ac.uk/31920 32185 A randomised controlled phase II trial of oral vinorelbine as second line therapy for patients with malignant pleural mesothelioma East Midlands http://public-odp.nihr.ac.uk/32185 32290 CheckpOiNt blockade For Inhibition of Relapsed Mesothelioma (CONFIRM): A Phase III Trial to Evaluate the Efficacy of Nivolumab in Relapsed Mesothelioma http://public-odp.nihr.ac.uk/32290 33998 A PHASE I/II TRIAL OF COMBINATION NAB-PACLITAXEL AND NINTEDANIB OR NAB-PACLITAXEL AND PLACEBO IN RELAPSED NSCLC ADENOCARCINOMA South London http://public-odp.nihr.ac.uk/33998 34870 Targeted therapy with or without dose intensified radiotherapy for oligo-progressive disease in oncogene-addicted lung tumours http://public-odp.nihr.ac.uk/34870

Cancer specialty objective for 2018-19 The following Objectives are extracted from the Draft Performance and Operating Framework 2018/19 (v0.9), which is yet to be approved by the Department of Health, and therefore, may be subject to change: Increase patient access to Cancer research studies across the breadth of the Cancer subspecialties Number of LCRNs achieving on-target recruitment into at least 8 of the 13 Cancer subspecialties, where "on- target" means either improving recruitment by 10% from 2017/18 or meeting the following recruitment targets per 100,000 population served: a) Brain: 0.2; b) Breast: 10 c); Colorectal: 3 d); Children and Young People: 3; e) Gynae: 3; f) Head & Neck: 1.5; g) Haematology: 7; h) Lung: 4; i) Sarcoma: 0.1; j) Skin: 0.5; k) Supportive & Palliative Care and Psychosocial Oncology: 4; l) Upper GI: 3; m) Urology: 12.

Useful links https://www.crn.nihr.ac.uk/ https://odp.nihr.ac.uk/ National and local network information including training programmes templates, tools, contacts, videos etc https://odp.nihr.ac.uk/ Open data platform. Look at performance across whole CRN including all specialty areas http://csg.ncri.org.uk/portfolio/portfolio-maps/ View current national portfolio of open, closed and ‘in set up’ cancer studies https://www.ukctg.nihr.ac.uk/ See where a study is open across the country http://public-odp.nihr.ac.uk/  Search for a study to fit criteria. Good for horizon scanning, eligibility criteria

Contacts Research Delivery Manager – David.Rea@nihr.ac.uk Research portfolio facilitator – jessica.bartlett@nihr.ac.uk Lung research lead – ashley.cox@nhs.net