Bone-Targeted Therapy in the Adjuvant Breast Cancer Setting

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Presentation transcript:

Bone-Targeted Therapy in the Adjuvant Breast Cancer Setting

Cancer-Treatment-Induced Bone Loss (CTIBL)

Clodronate and Bone Mineral Density (Hip)

Bone Mineral Density Substudy --ABCSG-12: Effect of Zoledronic Acid Percent Change, Lumbar Spine

Denosumab for CTIBL (Lumbar Spine)

Metastatic Niches in Bone Marrow

Differential Impact of Menopausal Status

The "Low Estrogen" Hypothesis

Adjuvant Bisphosphonate Treatment Breast Cancer Recurrence-Postmenopause*

Conclusions: EBCTCG Meta-Analysis

ABCSG-12 Trial Design

Adjuvant Denosumab in Breast Cancer (ABCSG-18, Phase 3) Primary Endpoint, First Clinical Fracture

Adjuvant Denosumab in Breast Cancer (ABCSG-18 Subgroup) Tumor Size > 2 cm

Bone-Targeting Therapy in Adjuvant Breast Cancer Setting Clinical Conclusions

References

References (cont)

References (cont)

Abbreviations

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