West of England Genomic Medicine Centre: Our Progress to Date Skin SSG 13th September 2017 Suriya Kirkpatrick, Genomic Champion Catherine Carpenter-Clawson, Programme Manager

100,000 Genomes project and genomic medicine - aims Initiative to perform Whole Genome Sequencing on 100,000 samples from NHS patients Make ‘genomic medicine’ part of standard care Diagnosis Prognosis Personalised treatment

Why would you want to be involved? West of England Genomics Medicine Centre – our objectives Complete whole genome sequencing of approx. 4,150 samples from patients & family. Both cancer and rare disease patients Access to programme across the region Actively consenting until Sept 2018 Facilitate integration of whole genome sequencing into standard clinical care pathways. Why would you want to be involved? Opportunity to conduct whole genome sequencing on key cohorts of cancer patients with an aim to improve understanding of the genomics of tumours and to support future of targeted therapies (Preparation for mainstreaming of genomic medicine as standard)

Phase 1. Contracting & pathway mapping Phase 2. Informatics & piloting Phase 3. Engagement & Expansion First RD consent RUH 22nd June First RD consent GHNFT 28th Mar First RD consent UHB 10th Jun 1,000 individuals enrolled 19th July First cancer consent GHNFT 11th Jan “Go-live” of cancer & RD pathways 27th May First cancer consent NBT 27th Jun First cancer consent RUH 19th May Designation as GMC 23rd Dec Jan 18 Jan 16 Jan 17 Launch event 26th Sep Annual Conference 1st Sep

Types of cancer eligible for inclusion Brain Head & Neck Breast Upper GI Lung Prostate Renal Endometrium Testicular Bladder Ovarian Colorectal Haematological Melanoma Paediatric Sarcoma Carcinoma Unknown Primary

Samples required

Proposed pathway How do you develop a pathway?

Proposed pathway How do you develop a pathway?

Proposed pathway How do you develop a pathway? – the key is engagement at every step of the pathway….. How do you develop a pathway?

Proposed pathway How do you develop a pathway?

Specimen transport team Patient Pathology GPs Imaging Consultants Surgeons Nursing staff Specialists Breast Care Nurses Research team Theatre team Clinic management MDT co-ordinators Specimen transport team IT experts How do you develop a pathway? – the key is engagement at every step of the pathway….. Tumour laboratory Blood laboratory Managers Reception Processing

Cancer planning by provider & pathway

What next? What else do we need to consider? I appreciate your continued interest and engagement. Any queries: Catherine Carpenter-Clawson Email: Catherine.Carpenter-Clawson@nbt.nhs.uk Tel: 07732 561067

Further Information http://www.wegmc.org/ https://www.genomicsengland.co.uk/ https://www.genomicseducation.hee.nhs.uk/