Identification of combination treatment–responsive effector/memory tumor-infiltrating CD8+ T cell population. Identification of combination treatment–responsive.

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Identification of combination treatment–responsive effector/memory tumor-infiltrating CD8+ T cell population. Identification of combination treatment–responsive effector/memory tumor-infiltrating CD8+ T cell population. (A) viSNE plots of tumor-infiltrating T cells overlaid with the expression of selected markers. (B) Density viSNE plots of OVA-specific tumor-infiltrating CD8+ T cells from each treatment group days 9 and 12 after tumor challenge. (C) viSNE plot of MC38 infiltrating OVA-specific CD8+ T cells overlaid with color-coded T cell clusters identified by SPADE. (D) Frequency of selected T cell clusters (means ± SEM). Indicated cluster was highlighted on viSNE plot below the bar graph. (E) FACS plots of CD44 and CD62L expression on cluster 11 compared with spleen T cell subsets. Tcm central memory T cells. (F) Histogram displaying the expression level of selected markers on T cell clusters. (G) Frequency of cytokine production of CD8+ T cells upon restimulation in vitro with OVA peptide. GzmB, granzyme B. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, one-way ANOVA with Tukey’s test). Bei Wang et al. Sci. Immunol. 2018;3:eaat7061 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works