Translational Informatics Applied to Drug Safety (TrIADS) Richard D. Boyce, PhD Assistant Professor Department of Biomedical Informatics University of Pittsburgh Faculty, Center for Pharmaceutical Policy and Prescribing Faculty, Geriatric Pharmaceutical Outcomes and Gero-Informatics Research and Training Program

A new paradigm for drug-drug interaction evidence and knowledge NLM R01LM011838 Dynamic enhancements Scientific literature Product labeling Semantic annotation pipeline Aim 1 Knowledge curation A framework for representing PDDI assertions and evidence as interoperable Linked Data available for community annotation Data driven: Synthesis of public PDDI sources Expert: Web-based scientific discourse Aim 2 Aim 3 More efficient synthesis of PDDI evidence, easier identification of gaps Reduced risk of a PDDI medication error! Expected benefits: More complete and accurate PDDI evidence Better informed pharmacists and other clinicians More effective PDDI alerting and decisions support systems

Interventions that improve drug safety for older adults NIA K01AG044433 Automated Observational Health Data Sciences and Informatics (OHDSI) LAERTES project Patient Specific Actionable

Research and Clinical Impact Google scholar h-index: 10 Selected Publication Boyce RD, Collins C, Horn J, Kalet I. Computing with evidence part II: an evidential approach to predicting metabolic drug-drug interactions, Journal of Biomedical Informatics, 2009 Dec;42(6):990-1003. PMCID : PMC2783683 Boyce RD, Horn JR, Hassanzadeh O, de Waard A, Schneider J, Luciano JS, Rastegar-Mojarad M, Liakata M. Dynamic enhancement of drug product labels to support drug safety, efficacy, and effectiveness. J Biomed Semantics. 2013 Jan 26;4(1):5. DOI 10.1186/2041-1480-4-5 PMID: 23351881. PMCID – PMC3698101 Boyce. RD., Ryan. PB., Noren. N., et al., Bridging islands of information to establish an integrated knowledge base of drugs and health outcomes of interest. Drug Safety. 2014. Volume 37, Issue 8 (2014), Page 557-567. DOI: 10.1007/s40264-014-0189-0, PubMed PMID: 24985530. PMCID: PMC4134480. Ayvaz S, Horn J, Hassanzadeh O, Zhu Q, Stan J, Tatonetti NP, Vilar S, Brochhausen M, Samwald M, Rastegar-Mojarad M, Dumontier M, Boyce RD, Toward a complete dataset of drug-drug interaction information from publicly available sources, Journal of Biomedical Informatics. 55 (2015), 206-217. DOI:10.1016/j.jbi.2015.04.006. PMCID: PMC4464899. Inventions “Pharmacogenomics Information System”, University of Pittsburgh Invention Disclosure Number 03041. 2013 “An automated multifactorial patient-specific fall risk intervention designed for the nursing home setting that includes consideration of potential drug-drug interactions”, University of Pittsburgh Invention Disclosure Number: 03647. 2015