CatSper channel, sperm function and male fertility

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Presentation transcript:

CatSper channel, sperm function and male fertility Akhand Pratap Singh, Singh Rajender Reproductive BioMedicine Online Volume 30, Issue 1, Pages 28-38 (January 2015) DOI: 10.1016/j.rbmo.2014.09.014 Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Sperm geometry: a mature spermatozoon consists of head, neck, mid-piece and tail. Head includes acrosome and nucleus whereas tail has principal piece and the end piece. Reproductive BioMedicine Online 2015 30, 28-38DOI: (10.1016/j.rbmo.2014.09.014) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Hypermotility: normal sperm display vigorous and asymmetrical flagellar beating termed as hypermotility, which is essential for propagation through viscous ovi-ductal fluid. CatSper null sperm show only basal motility and are unable to propagate to destination and penetrate protective layers of the egg. Reproductive BioMedicine Online 2015 30, 28-38DOI: (10.1016/j.rbmo.2014.09.014) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

Figure 3 Functioning and regulation of CatSper: Sperm Na+/H+ exchanger acts via cyclic adenosine monophosphate, which is generated in response to bicarbonate (HCO3-). CatSper channel is triggered by increase in intracellular pH, which allows calcium ions to enter in the sperm flagellar cytoplasm. Calcium balance inside the flagellum is maintained by Ca2+ adenosine triphosphatase pumps, which export intracellular Ca2+ ion and import extracellular protons. The resulting acidification is regulated by proton extrusion via Voltage-gated H+ channel 1 (Hv1) channel. Sperm specific K+ channel (SLO3) maintains flagellar membrane potential. Reproductive BioMedicine Online 2015 30, 28-38DOI: (10.1016/j.rbmo.2014.09.014) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions

Figure 4 Functional significance of CatSper: The protective barriers offer a challenge to sperm. CatSper helps in penetration of zona pellucida layer such that CatSper null sperm are unable to penetrate this layer, failing to fertilize the egg. Reproductive BioMedicine Online 2015 30, 28-38DOI: (10.1016/j.rbmo.2014.09.014) Copyright © 2014 Reproductive Healthcare Ltd. Terms and Conditions