2013 Cholesterol Guidelines Revisited: Percent LDL Cholesterol Reduction or Attained LDL Cholesterol Level or Both for Prognosis? Sripal Bangalore, MD,

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Presentation transcript:

2013 Cholesterol Guidelines Revisited: Percent LDL Cholesterol Reduction or Attained LDL Cholesterol Level or Both for Prognosis? Sripal Bangalore, MD, MHA, Rana Fayyad, PhD, John J. Kastelein, MD, Rachel Laskey, PhD, Pierre Amarenco, MD, David A. DeMicco, PharmD, David D. Waters, MD The American Journal of Medicine Volume 129, Issue 4, Pages 384-391 (April 2016) DOI: 10.1016/j.amjmed.2015.10.024 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Major cardiovascular events in the cohort with attained LDL-C ≤70 mg/dL as a function of percent LDL-C reduction. LDL = low-density lipoprotein. The American Journal of Medicine 2016 129, 384-391DOI: (10.1016/j.amjmed.2015.10.024) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 2 Major cardiovascular events in the cohort with attained LDL-C >70 mg/dL as a function of percent LDL-C reduction. LDL = low-density lipoprotein. The American Journal of Medicine 2016 129, 384-391DOI: (10.1016/j.amjmed.2015.10.024) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 3 Incremental prognostic value of percent LDL-C reduction from baseline over statin dose and attained LDL-C levels. CV = cardiovascular; LDL-C = low-density lipoprotein cholesterol. The American Journal of Medicine 2016 129, 384-391DOI: (10.1016/j.amjmed.2015.10.024) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 4 Incremental prognostic value of attained LDL-C levels over statin dose and percent LDL-C reduction. CV = cardiovascular; LDL-C = low-density lipoprotein cholesterol. The American Journal of Medicine 2016 129, 384-391DOI: (10.1016/j.amjmed.2015.10.024) Copyright © 2016 Elsevier Inc. Terms and Conditions