Thrombotic Microangiopathy Associated with Sirolimus Level after Allogeneic Hematopoietic Cell Transplantation with Tacrolimus/Sirolimus-Based Graft-versus-Host.

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Presentation transcript:

Thrombotic Microangiopathy Associated with Sirolimus Level after Allogeneic Hematopoietic Cell Transplantation with Tacrolimus/Sirolimus-Based Graft-versus-Host Disease Prophylaxis Sepideh Shayani, Joycelynne Palmer, Tracey Stiller, Xueli Liu, Sandra H. Thomas, Tam Khuu, Pablo M. Parker, Samer K. Khaled, Stephen J. Forman, Ryotaro Nakamura Biology of Blood and Marrow Transplantation Volume 19, Issue 2, Pages 298-304 (February 2013) DOI: 10.1016/j.bbmt.2012.10.006 Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Cumulative incidence of aGVHD and TMA in the first 100 days posttransplantation. (A) Time to onset of grade II-IV aGVHD. (B) Time to onset of definitive TMA, with death before 100 days calculated as a competing risk. Biology of Blood and Marrow Transplantation 2013 19, 298-304DOI: (10.1016/j.bbmt.2012.10.006) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 NRM stratified by presence of TMA. Time to death from nonrelapse causes calculated with relapse, progression, or second transplantation as competing risks. The dashed line represents patients with definitive TMA (based on laboratory criteria). Biology of Blood and Marrow Transplantation 2013 19, 298-304DOI: (10.1016/j.bbmt.2012.10.006) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions