Heparin-coated cardiopulmonary bypass equipment. II

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Heparin-coated cardiopulmonary bypass equipment. II Heparin-coated cardiopulmonary bypass equipment. II. Mechanisms for reduced complement activation in vivo Vibeke Videm, MD, PhD, Tom Eirik Mollnes, MD, PhD, Kåre Bergh, MD, PhD, Erik Fosse, MD, PhD, Brit Mohr, MD, Tor-Arne Hagve, MD, PhD, Ansgar O. Aasen, MD, PhD, Jan L. Svennevig, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 117, Issue 4, Pages 803-809 (April 1999) DOI: 10.1016/S0022-5223(99)70302-8 Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig 1 Simplified overview of the complement cascade. C4bC2a and C3bBb are the classical and alternative C3 convertases, respectively. C4aC2aC3b and C3bBbC3b are the corresponding classical and alternative C5 convertases. See text for further details. The Journal of Thoracic and Cardiovascular Surgery 1999 117, 803-809DOI: (10.1016/S0022-5223(99)70302-8) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 2 Classical complement activation (median and 95% confidence intervals) by median sampling times in patients undergoing aorta-coronary bypass operations with (n = 15) and without (n = 14) Duraflo II heparin-coated CPB circuits. A, Plasma concentrations of C1rs-C1 inhibitor complexes. Groups were significantly different (P = .03, ANOVA). B, Plasma concentrations of C4 activation products (C4bc). Groups were not significantly different (P = .69, ANOVA). The Journal of Thoracic and Cardiovascular Surgery 1999 117, 803-809DOI: (10.1016/S0022-5223(99)70302-8) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig 3 Plasma concentrations of activated factor B (Bb) (median and 95% confidence intervals) by median sampling times in patients undergoing aorta-coronary bypass operations with (n = 15) and without (n = 14) Duraflo II heparin-coated CPB circuits. Groups were not significantly different (P = .22, ANOVA). The Journal of Thoracic and Cardiovascular Surgery 1999 117, 803-809DOI: (10.1016/S0022-5223(99)70302-8) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig 4 Plasma concentrations of C3 activation products (C3bc) (median and 95% confidence intervals) by median sampling times in patients undergoing aorta-coronary bypass operations with (n = 15) and without (n = 14) Duraflo II heparin-coated CPB circuits. Groups were significantly different (P = .03, ANOVA). The Journal of Thoracic and Cardiovascular Surgery 1999 117, 803-809DOI: (10.1016/S0022-5223(99)70302-8) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig 5 Terminal complement activation (median and 95% confidence intervals) by median sampling times in patients undergoing aorta-coronary bypass operations with (n = 15) and without (n = 14) Duraflo II heparin-coated CPB circuits. A, Plasma concentrations of C5a-desArg. Groups were not significantly different (P = .13, ANOVA). B, Plasma concentrations of the TCC. Groups were significantly different (P =.004, ANOVA). The Journal of Thoracic and Cardiovascular Surgery 1999 117, 803-809DOI: (10.1016/S0022-5223(99)70302-8) Copyright © 1999 Mosby, Inc. Terms and Conditions