The Structure and Function of Large Biological Molecules

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Presentation transcript:

The Structure and Function of Large Biological Molecules Chapter 5 The Structure and Function of Large Biological Molecules

Overview: The Molecules of Life All living things are made up of four classes of large biological molecules: carbohydrates, lipids, proteins, and nucleic acids Within cells, small organic molecules are joined together to form larger molecules Macromolecules are large molecules composed of thousands of covalently connected atoms Molecular structure and function are inseparable Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

Fig. 5-1 Figure 5.1 Why do scientists study the structures of macromolecules?

Concept 5.1: Macromolecules are polymers, built from monomers A polymer is a long molecule consisting of many similar building blocks These small building-block molecules are called monomers Three of the four classes of life’s organic molecules are polymers: Carbohydrates Proteins Nucleic acids Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

The Synthesis and Breakdown of Polymers A condensation reaction or more specifically a dehydration reaction occurs when two monomers bond together through the loss of a water molecule Enzymes are macromolecules that speed up the dehydration process Polymers are disassembled to monomers by hydrolysis, a reaction that is essentially the reverse of the dehydration reaction Animation: Polymers Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

Dehydration removes a water molecule, forming a new bond H2O Fig. 5-2 HO 1 2 3 H HO H Short polymer Unlinked monomer Dehydration removes a water molecule, forming a new bond H2O HO 1 2 3 4 H Longer polymer (a) Dehydration reaction in the synthesis of a polymer HO 1 2 3 4 H Figure 5.2 The synthesis and breakdown of polymers Hydrolysis adds a water molecule, breaking a bond H2O HO 1 2 3 H HO H (b) Hydrolysis of a polymer

Dehydration removes a water molecule, forming a new bond H2O Fig. 5-2a HO 1 2 3 H HO H Short polymer Unlinked monomer Dehydration removes a water molecule, forming a new bond H2O Figure 5.2 The synthesis and breakdown of polymers HO 1 2 3 4 H Longer polymer (a) Dehydration reaction in the synthesis of a polymer

HO 1 2 3 4 H H2O HO 1 2 3 H HO H (b) Hydrolysis adds a water Fig. 5-2b HO 1 2 3 4 H Hydrolysis adds a water molecule, breaking a bond H2O Figure 5.2 The synthesis and breakdown of polymers HO 1 2 3 H HO H (b) Hydrolysis of a polymer

The Diversity of Polymers Each cell has thousands of different kinds of macromolecules Macromolecules vary among cells of an organism, vary more within a species, and vary even more between species An immense variety of polymers can be built from a small set of monomers 2 3 H HO Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

Concept 5.2: Carbohydrates serve as fuel and building material Carbohydrates include sugars and the polymers of sugars The simplest carbohydrates are monosaccharides, or single sugars Carbohydrate macromolecules are polysaccharides, polymers composed of many sugar building blocks Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

Glucose (C6H12O6) is the most common monosaccharide Sugars Monosaccharides have molecular formulas that are usually multiples of CH2O Glucose (C6H12O6) is the most common monosaccharide Monosaccharides are classified by The location of the carbonyl group (as aldose or ketose) The number of carbons in the carbon skeleton Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

Aldoses Glyceraldehyde Ribose Glucose Galactose Ketoses Fig. 5-3 Trioses (C3H6O3) Pentoses (C5H10O5) Hexoses (C6H12O6) Aldoses Glyceraldehyde Ribose Glucose Galactose Figure 5.3 The structure and classification of some monosaccharides Ketoses Dihydroxyacetone Ribulose Fructose

Trioses (C3H6O3) Pentoses (C5H10O5) Hexoses (C6H12O6) Aldoses Fig. 5-3a Trioses (C3H6O3) Pentoses (C5H10O5) Hexoses (C6H12O6) Aldoses Glyceraldehyde Figure 5.3 The structure and classification of some monosaccharides Ribose Glucose Galactose

Trioses (C3H6O3) Pentoses (C5H10O5) Hexoses (C6H12O6) Ketoses Fig. 5-3b Trioses (C3H6O3) Pentoses (C5H10O5) Hexoses (C6H12O6) Ketoses Dihydroxyacetone Figure 5.3 The structure and classification of some monosaccharides Ribulose Fructose

Though often drawn as linear skeletons, in aqueous solutions many sugars form rings Monosaccharides serve as a major fuel for cells and as raw material for building molecules Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

(a) Linear and ring forms (b) Abbreviated ring structure Fig. 5-4 (a) Linear and ring forms Figure 5.4 Linear and ring forms of glucose (b) Abbreviated ring structure

(a) Linear and ring forms Fig. 5-4a Figure 5.4 Linear and ring forms of glucose (a) Linear and ring forms

(b) Abbreviated ring structure Fig. 5-4b Figure 5.4 Linear and ring forms of glucose (b) Abbreviated ring structure

Animation: Disaccharides A disaccharide is formed when a dehydration reaction joins two monosaccharides This covalent bond is called a glycosidic linkage Animation: Disaccharides Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

(a) Dehydration reaction in the synthesis of maltose Fig. 5-5 1–4 glycosidic linkage Glucose Glucose Maltose (a) Dehydration reaction in the synthesis of maltose 1–2 glycosidic linkage Figure 5.5 Examples of disaccharide synthesis Glucose Fructose Sucrose (b) Dehydration reaction in the synthesis of sucrose

Polysaccharides Polysaccharides, the polymers of sugars, have storage and structural roles The structure and function of a polysaccharide are determined by its sugar monomers and the positions of glycosidic linkages Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

Storage Polysaccharides Starch, a storage polysaccharide of plants, consists entirely of glucose monomers Plants store surplus starch as granules within chloroplasts and other plastids Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

(a) Starch: a plant polysaccharide Fig. 5-6 Chloroplast Starch Mitochondria Glycogen granules 0.5 µm 1 µm Figure 5.6 Storage polysaccharides of plants and animals Amylose Glycogen Amylopectin (a) Starch: a plant polysaccharide (b) Glycogen: an animal polysaccharide

Glycogen is a storage polysaccharide in animals Humans and other vertebrates store glycogen mainly in liver and muscle cells Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

Structural Polysaccharides The polysaccharide cellulose is a major component of the tough wall of plant cells Like starch, cellulose is a polymer of glucose, but the glycosidic linkages differ The difference is based on two ring forms for glucose: alpha () and beta () Animation: Polysaccharides Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

(b) Starch: 1–4 linkage of  glucose monomers Fig. 5-7 (a)  and  glucose ring structures  Glucose  Glucose Figure 5.7 Starch and cellulose structures (b) Starch: 1–4 linkage of  glucose monomers (b) Cellulose: 1–4 linkage of  glucose monomers

(a)  and  glucose ring structures Fig. 5-7a  Glucose  Glucose Figure 5.7 Starch and cellulose structures (a)  and  glucose ring structures

(b) Starch: 1–4 linkage of  glucose monomers Fig. 5-7bc (b) Starch: 1–4 linkage of  glucose monomers Figure 5.7 Starch and cellulose structures (c) Cellulose: 1–4 linkage of  glucose monomers

Polymers with  glucose are helical Polymers with  glucose are straight In straight structures, H atoms on one strand can bond with OH groups on other strands Parallel cellulose molecules held together this way are grouped into microfibrils, which form strong building materials for plants Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

Cell walls Cellulose microfibrils in a plant cell wall Microfibril Fig. 5-8 Cell walls Cellulose microfibrils in a plant cell wall Microfibril 10 µm 0.5 µm Cellulose molecules Figure 5.8 The arrangement of cellulose in plant cell walls Glucose monomer

Some microbes use enzymes to digest cellulose Enzymes that digest starch by hydrolyzing  linkages can’t hydrolyze  linkages in cellulose Cellulose in human food passes through the digestive tract as insoluble fiber Some microbes use enzymes to digest cellulose Many herbivores, from cows to termites, have symbiotic relationships with these microbes Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

Fig. 5-9 Figure 5.9 Cellulose-digesting prokaryotes are found in grazing animals such as this cow

Chitin, another structural polysaccharide, is found in the exoskeleton of arthropods Chitin also provides structural support for the cell walls of many fungi Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings

(a) The structure of the chitin monomer. (b) (c) Chitin forms the Fig. 5-10 (a) The structure of the chitin monomer. (b) Chitin forms the exoskeleton of arthropods. (c) Chitin is used to make a strong and flexible surgical thread. Figure 5.10 Chitin, a structural polysaccharide