Gene expression of vascular endothelial growth factor and its receptors and angiogenesis in bronchial asthma Makoto Hoshino, MDa, Yutaka Nakamura, MDa,

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Gene expression of vascular endothelial growth factor and its receptors and angiogenesis in bronchial asthma Makoto Hoshino, MDa, Yutaka Nakamura, MDa, Qutayba A. Hamid, MD, PhDb Journal of Allergy and Clinical Immunology Volume 107, Issue 6, Pages 1034-1038 (June 2001) DOI: 10.1067/mai.2001.115626 Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 1 a , Hematoxylin and eosin staining of bronchial biopsy specimens from asthmatic subjects. b , In situ hybridization of VEGF mRNA by using complementary RNA probe (sulfur 35–labeled) visualized by autoradiography and dark-field illumination in bronchial biopsy specimens from asthmatic subjects. c , Dark-field illumination of in situ hybridization for flt-1 in asthmatic airways. d , Bright-field illumination of flk-1 in bronchial biopsy specimens from asthmatic subjects. e , Simultaneous in situ hybridization and immunocytochemistry in bronchial biopsy specimens from asthmatic subjects showing colocalization of VEGF and CD68. f , In situ hybridization of VEGF dark field in asthmatic lungs. g , Double staining of major basic protein and VEGF mRNA. Journal of Allergy and Clinical Immunology 2001 107, 1034-1038DOI: (10.1067/mai.2001.115626) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 2 Number of VEGF (A) , flt-1 (B) , and flk-1 (C) mRNA+ cells per square millimeter of submucosa measured by means of in situ hybridization in bronchial biopsy specimens from asthmatic (n = 11) and control subjects (n = 8). Group values are presented as medians with interquartile ranges. Journal of Allergy and Clinical Immunology 2001 107, 1034-1038DOI: (10.1067/mai.2001.115626) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 3 Correlation between the percentage of vascularity and VEGF mRNA+ (A) , flt-1 mRNA+ (B) , and flk-1 mRNA+ (C) cells. Correlations are significant only for asthmatic patients. Filled circles, Asthmatic patients; open circles, control subjects. Journal of Allergy and Clinical Immunology 2001 107, 1034-1038DOI: (10.1067/mai.2001.115626) Copyright © 2001 Mosby, Inc. Terms and Conditions