Volume 117, Issue 1, Pages 154-160 (July 1999) p53 mutations in British patients with hepatocellular carcinoma: Clustering in genetic hemochromatosis  Guy Vautier*, Adrian B. Bomford‡, Bernard C. Portmann‡, Elizabeth Metivier‡, Roger Williams‡, Stephen D. Ryder*  Gastroenterology  Volume 117, Issue 1, Pages 154-160 (July 1999) DOI: 10.1016/S0016-5085(99)70562-7 Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 1 Site of p53 mutations in 50 British patients with HCC. Gastroenterology 1999 117, 154-160DOI: (10.1016/S0016-5085(99)70562-7) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 2 Site of mutation within p53 according to origin of liver disease. (A) Alcoholic liver disease; (B) hepatitis C; (C) hemochromatosis; (D) hepatitis B. The frequency of the codon 220 A to G mutation is significantly more frequent in GH-related HCCs than HCCs of other etiologies (P = 0.0001, χ2 test). Gastroenterology 1999 117, 154-160DOI: (10.1016/S0016-5085(99)70562-7) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 2 Site of mutation within p53 according to origin of liver disease. (A) Alcoholic liver disease; (B) hepatitis C; (C) hemochromatosis; (D) hepatitis B. The frequency of the codon 220 A to G mutation is significantly more frequent in GH-related HCCs than HCCs of other etiologies (P = 0.0001, χ2 test). Gastroenterology 1999 117, 154-160DOI: (10.1016/S0016-5085(99)70562-7) Copyright © 1999 American Gastroenterological Association Terms and Conditions