Volume 134, Issue 4, Pages 945-952 (April 2008) Gastric Cancer Risk in Patients With Premalignant Gastric Lesions: A Nationwide Cohort Study in the Netherlands  Annemarie C. de Vries, Nicole C.T. van Grieken, Caspar W.N. Looman, Mariël K. Casparie, Esther de Vries, Gerrit A. Meijer, Ernst J. Kuipers  Gastroenterology  Volume 134, Issue 4, Pages 945-952 (April 2008) DOI: 10.1053/j.gastro.2008.01.071 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 The proportion of patients with atrophic gastritis, intestinal metaplasia, and dysplasia receiving 1 or more follow-up upper-gastrointestinal endoscopies. Gastroenterology 2008 134, 945-952DOI: (10.1053/j.gastro.2008.01.071) Copyright © 2008 AGA Institute Terms and Conditions

Figure 2 The proportion of patients with atrophic gastritis, intestinal metaplasia, and dysplasia receiving histological follow-up according to 5-year age categories. Gastroenterology 2008 134, 945-952DOI: (10.1053/j.gastro.2008.01.071) Copyright © 2008 AGA Institute Terms and Conditions

Figure 3 Timing of re-examination in patients who received histological re-evaluation of premalignant gastric lesions. Gastroenterology 2008 134, 945-952DOI: (10.1053/j.gastro.2008.01.071) Copyright © 2008 AGA Institute Terms and Conditions

Figure 4 Follow-up results in patients in whom histological re-evaluation was performed. The results are presented as most advanced gastric lesion during follow-up for each category of premalignant gastric lesions at baseline. The outcome of patients who developed esophageal or cancer at the esophagogastric junction is not mentioned in this figure. Mean length of follow-up for patients with atrophic gastritis, intestinal metaplasia, mild-to-moderate dysplasia, and severe dysplasia: 3.5, 2.8, 2.5, and 1.0 years, respectively. Gastroenterology 2008 134, 945-952DOI: (10.1053/j.gastro.2008.01.071) Copyright © 2008 AGA Institute Terms and Conditions

Figure 5 Progression rate of premalignant gastric lesions to gastric cancer in 92,250 patients with premalignant gastric lesions (90,780 censored patients). Gastroenterology 2008 134, 945-952DOI: (10.1053/j.gastro.2008.01.071) Copyright © 2008 AGA Institute Terms and Conditions

Figure 6 Progression from intestinal metaplasia to gastric adenocarcinoma after 10 years’ follow-up within the same patient. (A) Gastric mucosa (corpus) showing mild gastritis with marked intestinal metaplasia, no dysplasia (1993). (B) Gastric mucosa (angulus) showing moderately differentiated gastric adenocarcinoma (2003). H&E staining, original magnification x100. Gastroenterology 2008 134, 945-952DOI: (10.1053/j.gastro.2008.01.071) Copyright © 2008 AGA Institute Terms and Conditions