Announcements Homework due Wednesday, 4/16/08.

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Presentation transcript:

Announcements Homework due Wednesday, 4/16/08. Also Wednesday, turn in your final paper’s topic. Again, research paper and general review article. You’ll give a talk and a 10 page paper– on exact same topic.

How Ion Channels Move to Create Action Potentials

Action Potential– Nerves Firing 2. 3. 1. 4. 5. http://www.biologymad.com/NervousSystem/nerveimpulses.htm

Is the Ion Channel Digital or Analog?

Charged amino acids (largely in the voltage sensor) move.

(e.g. Lysines, Arginines, etc.)– That’s voltage sensor. For this particular channel, equally likely to be open as closed at -30mV. Qe ~ 13e charges/channel for Na+,K+ Look for part of channel which has 13 charges! (e.g. Lysines, Arginines, etc.)– That’s voltage sensor.

S6 in K+ Channel S5 in K+ Channel M2 in original (KcsA) structure: M1 in original structure S5 in K+ Channel

KcsA Potassium Channel (Bacteria) Tetramer of M1, M2 (analogous to S5, S6) Nobel Prize- 2003, Rod MacKinnon

Sodium channel been crystallized. C=O just right for Na+. Hydration Energy If 10,000 fold selectivity, what is ENa vs. EK ? Ans: 9.2kT Sodium channel been crystallized. C=O just right for Na+.

Sodium Channel has Similar Structure Bezanilla, 2008, Nature Reviews

Inside Outside

S1-S4 Voltage Sensor Lies on the Outside of S5/S6 Crystal Structure of S1-S6 Ion Channel Nobel Prize for Rod MacKinnon, 2006 (There were real problems with this structure.) S1-S4 Voltage Sensor Lies on the Outside of S5/S6

Answer, and turn in at the end of class. Class evaluation What was the most interesting thing you learned in class today? 2. What are you confused about? 3. Related to today’s subject, what would you like to know more about? 4. Any helpful comments. Answer, and turn in at the end of class.