Cristina Teodosio, MSc, Andrés C

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Gene expression profile of highly purified bone marrow mast cells in systemic mastocytosis Cristina Teodosio, MSc, Andrés C. García-Montero, PhD, María Jara-Acevedo, MSc, Laura Sánchez-Muñoz, MD, PhD, Carlos E. Pedreira, PhD, Ivan Álvarez-Twose, MD, Sergio Matarraz, PhD, José M. Morgado, MSc, Paloma Bárcena, MSc, Almudena Matito, MD, Andrea Mayado, PhD, Maria Luz Sanchez, PhD, María Diez-Campelo, MD, PhD, Luis Escribano, MD, PhD, Alberto Orfao, MD, PhD Journal of Allergy and Clinical Immunology Volume 131, Issue 4, Pages 1213-1224.e4 (April 2013) DOI: 10.1016/j.jaci.2012.12.674 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Altered GEPs common to the distinct subtypes of SM (ISM and ASM): network pathway analysis of those genes that have been associated with the immune response, that have been previously described to be regulated by or to interact with KIT, or both. Upregulated genes are depicted in red; the color intensity reflects the fold-change levels versus those observed in normal/reactive BMMCs. Journal of Allergy and Clinical Immunology 2013 131, 1213-1224.e4DOI: (10.1016/j.jaci.2012.12.674) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Discrimination between patients with ISM and those with ASM based on a restricted number of genes differentially expressed by BMMCs. Gene expression levels (GEPs) of those genes that contributed to the discrimination between ISM and ASM are shown by color codes in the left column. Centroid plots are shown in the middle column, whereas gene expression charts on the right display medians ± 95% CIs. AU, Log-transformed fluorescence arbitrary units; N/R BMMC, normal/reactive BMMCs. Journal of Allergy and Clinical Immunology 2013 131, 1213-1224.e4DOI: (10.1016/j.jaci.2012.12.674) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Immunophenotypic characteristics (A-J; mean fluorescence intensity [MFI] values per MC) and PI values (percentage of S plus G2/M cells) of BMMCs (K) from patients with SM compared with normal/reactive BMMCs (CONTROL). Journal of Allergy and Clinical Immunology 2013 131, 1213-1224.e4DOI: (10.1016/j.jaci.2012.12.674) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions