An improved orthotopic xenotransplant procedure for human lung cancer in SCID bg mice Arnd S Boehle, MD, Peter Dohrmann, PhD, Ivo Leuschner, MD, Holger.

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An improved orthotopic xenotransplant procedure for human lung cancer in SCID bg mice Arnd S Boehle, MD, Peter Dohrmann, PhD, Ivo Leuschner, MD, Holger Kalthoff, PhD, Doris Henne-Bruns, PhD The Annals of Thoracic Surgery Volume 69, Issue 4, Pages 1010-1015 (April 2000) DOI: 10.1016/S0003-4975(00)01090-0

Fig 1 Squamous cell carcinoma. Light microscopy shows middle-sized cells forming solid complexes. The cytoplasm appears relatively wide and moderately eosinophilic. In some areas, larger cells display a broader, almost clear cytoplasm. A marked squamoid differentiation of these cells is obvious. Desmosomes can be detected focally. The nuclei appear ovoid. The chromatin is slightly granular. There are numerous mitotic figures. The tumors appear to have a relative sharp border and display a moderate invasion into the surrounding tissue (Hematoxylin & eosin; ×80). The Annals of Thoracic Surgery 2000 69, 1010-1015DOI: (10.1016/S0003-4975(00)01090-0)

Fig 2 Adenocarcinoma. The tumors appear as solid groups of relatively small uniform cells. The nuclei appear ovoid and moderately pleomorphic. The chromatin is granular. Infrequently tubulus-like structures can be identified. The proliferation rate is moderate. Areas of necrosis can be identified. The tumor grows moderately infiltrating into the surrounding tissue (Hematoxylin & eosin; ×160). The Annals of Thoracic Surgery 2000 69, 1010-1015DOI: (10.1016/S0003-4975(00)01090-0)

Fig 3 Large cell carcinoma. The tumor cells form large solid complexes. An organoid structure cannot be identified. The cells show a distinct polymorphism and are of variable size. The cytoplasm is moderately eosinophilic. Focally, the nuclei have a distinct pleomorphic and hyperchromatic pattern. Mitotic activity is high. In the centers, necrotic areas are visible. Tumor cells show a marked invasion into the surrounding tissue (Hematoxylin & eosin; ×160). The Annals of Thoracic Surgery 2000 69, 1010-1015DOI: (10.1016/S0003-4975(00)01090-0)