Cancer Metabolism: A New Treatment Approach

Program Goals

Overview

History of Cancer Metabolism

Abnormal Metabolic Pathways in Cancer

Sources of ATP Energy for Normal and Malignant Cells Under Varied Oxygenation

Role of Oncogenes and Tumor Suppressor Genes

Overexpression of c-MYC in Cancer

Targeting Glycolysis in Cancer

Hereditary Syndromes

Role of TET2 in DNA Methylation

TET2 Mutation in Hematologic Malignancies

TET2 Mutations Are Prevalent in Healthy Older Adults

IDH Mutations in Cancer

IDH Mutations in Cancer Development

IDH Mutations Cause an Oncometabolic Gain-of-Function

Targeting IDH Metabolically

IDH Mutations in Myeloid Malignancies

Frequency of IDH Mutations in Different Cancer Types

2-HG as Therapeutic Target and Tumor Biomarker

IDH Inhibition in Cancer Proof of Principle

IDH Inhibition in Cancer Principle to Practice

Conclusions

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