PCP Perspectives Pathophysiologic Principles in the Management of Hyperkalemia

Fluid and Electrolyte Balance Under Tight Control

Electrolyte Movement Between Compartments

Serum Potassium Homeostasis and Regulation

Introduction to Hyperkalemia

Predictors of Hyperkalemia[a]

Hyperkalemia Management

Acute Management of Hyperkalemia

Standard Care of Chronic Hyperkalemia

High–Potassium-Containing Foods

Other Hidden Sources of Potassium

Medications Associated With Hyperkalemia

Diuretic Use in the Management of Chronic Hyperkalemia

GI Tract Cation Concentration

Sodium Polystyrene Sulfonate

Patiromer

Opal-HK Phase 3 Trial Study Design

Initial Treatment Phase Demographics and Baseline Characteristics

Baseline RAAS Inhibitor and Diuretic Medications

Initial Treatment Phase Primary and Secondary Efficacy Endpoints

Randomized Withdrawal Phase Time to First Recurrent Hyperkalemia Event*

Initial Treatment Phase Adverse Events While on Patiromer

Investigational Potassium Binder ZS-9*

2-Phase, Dose-Ranging Trial of ZS-9 Study Design

Potassium Levels During the Acute and Maintenance Phase

ZS-9 Adverse Events

Engaging Patients in the Management of their Chronic Disease

Concluding Remarks

Abbreviations

Abbreviations